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Invitrogen
MyD88 Monoclonal Antibody (4D6)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-16231
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rhesus monkey
Published species
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
4D6
Immunogen
A portion of amino acids 50-100 of human MyD88.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.0 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Myeloid differentiation Marker 88 (MyD88) is an adaptor molecule for the Toll/IL-1R and is involved in the inflammatory response induced by IL-1, IL-18 and LPS. MyD88 recruits IRAK to IL-1 receptor complex in response to IL-1. This pathway further leads to activation of NF-kB. MyD88 has a wide tissue distribution.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: mutant myeloid differentiation primary response 88; myeloid differentiation primary response 88; myeloid differentiation primary response gene (88); myeloid differentiation primary response protein 88; Myeloid differentiation primary response protein MyD88; myleoid differentiation primary response protein; TLR adaptor MYD88; unnamed protein product
Gene Aliases: IMD68; MYD88; MYD88D; WM1
UniProt ID: (Rhesus monkey) B3Y683, (Mouse) P22366
Entrez Gene ID: (Human) 4615, (Rhesus monkey) 696494, (Mouse) 17874
receptor binding
Toll binding
death receptor binding
cytokine receptor binding
interleukin-1 receptor binding
protein binding
Toll-like receptor binding
signaling adaptor activity
identical protein binding
binding, bridging
TIR domain binding
ATP-dependent histone chaperone activity
scaffold/adaptor protein
toll-like receptor signaling pathway
MyD88-dependent toll-like receptor signaling pathway
chromatin organization
chromatin remodeling
phagocytosis
apoptotic process
signal transduction
cell surface receptor signaling pathway
I-kappaB kinase/NF-kappaB signaling
JNK cascade
Toll signaling pathway
gene expression
positive regulation of gene expression
response to amine
cytokine-mediated signaling pathway
lipopolysaccharide-mediated signaling pathway
positive regulation of type I interferon production
positive regulation of interleukin-1 beta production
positive regulation of interleukin-17 production
positive regulation of interleukin-23 production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
toll-like receptor 4 signaling pathway
toll-like receptor 5 signaling pathway
toll-like receptor 8 signaling pathway
toll-like receptor 9 signaling pathway
toll-like receptor TLR6:TLR2 signaling pathway
interleukin-33-mediated signaling pathway
defense response to bacterium
defense response to protozoan
positive regulation of I-kappaB kinase/NF-kappaB signaling
response to amino acid
regulation of MAP kinase activity
skin development
NLRP3 inflammasome complex assembly
innate immune response
response to ethanol
positive regulation of transcription from RNA polymerase II promoter
positive regulation of smooth muscle cell proliferation
regulation of inflammatory response
defense response to Gram-positive bacterium
defense response to virus
type I interferon signaling pathway
interleukin-1-mediated signaling pathway
response to interleukin-1
3'-UTR-mediated mRNA stabilization
cellular response to lipopolysaccharide
cellular response to mechanical stimulus
cellular response to oxidised low-density lipoprotein particle stimulus
positive regulation of cytokine production involved in inflammatory response
positive regulation of NLRP3 inflammasome complex assembly
response to molecule of fungal origin
immune system process
inflammatory response
immune response
transmembrane receptor protein serine/threonine kinase signaling pathway
response to virus
immunoglobulin mediated immune response
response to peptidoglycan
response to lipopolysaccharide
positive regulation of tumor necrosis factor production
regulation of cell proliferation
negative regulation of growth of symbiont in host
positive regulation of chemokine biosynthetic process
type I interferon biosynthetic process
positive regulation of JNK cascade
positive regulation of lymphocyte proliferation
positive regulation of NF-kappaB transcription factor activity
establishment of endothelial intestinal barrier
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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