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HLA-DR Monoclonal Antibody (37.68), FITC

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HLA-DR Monoclonal Antibody (37.68), FITC

产品信息

MA5-16502

应用
建议稀释比
已发表文章

流式细胞分析 (Flow)

1:5-1:10
-
产品规格

种属反应

Bovine, Goat, Human, Mouse, Sheep

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

37.68

抗原

Splenocytes from ATL mice (1)
3D表位/免疫原

偶联物

FITC FITC FITC

激发/发射光谱

498/517 nm 查看光谱 spectra

形式

Liquid

浓度

0.1 mg/mL

规格

100 µg

纯化类型

Protein A

保存液

PBS with 1% BSA

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2538013

产品详细信息

For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.

靶标信息

HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response.

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: BoLA-DR-alpha; BoLA-DRB3.2; CD74; CD74 antigen; CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); CD74 molecule, major histocompatibility complex, class II invariant chain; class II-associated invariant chain peptide; DASS-397D15.1; dinucleotide microsatellite; DR beta-5; DR beta-chain antigen binding domain; DR-beta chain MHC class II; DR2-beta-2; Dw2; FLJ51114; FLJ75017; FLJ76359; H-2 class II histocompatibility antigen gamma chain; H-2 class II histocompatibility antigen, E-D alpha chain; H-2 class II histocompatibility antigen, E-K alpha chain; H-2 class II histocompatibility antigen, E-U alpha chain; H2-IE-alpha; histocompatibility 2, class II antigen E alpha; histocompatibility complex, class II, DR beta 3; histocompatibility: class II antigens, gamma chain of; HLA class II histocompatibility antigen gamma chain; HLA class II histocompatibility antigen, DR alpha chain; HLA class II histocompatibility antigen, DR beta 3 chain; HLA class II histocompatibility antigen, DR beta 4 chain; HLA class II histocompatibility antigen, DR beta 5 chain; HLA class II histocompatibility antigen, DRB1 beta chain; HLA-DR antigens-associated invariant chain; HLA-DR-GAMMA; HLA-DRB1; Human leukocyte antigen DRB1; I-E alpha MHC class II; Ia antigen-associated invariant chain; Ia-associated invariant chain; Ii; invariant polypeptide of major histocompatibility complex, class II antigen-associated; leukocyte antigen DRB3; major histocompatibility complex class II DR-beta chain; major histocompatibility complex, class II, DR beta 3; MHC class II antigen beta chain; MHC class II antigen BoLA-DRB3; MHC class II antigen DRA; MHC class II antigen DRB3; MHC class II antigen DRB4; MHC class II antigen DRB5; MHC class II antigen E alpha; MHC class II DR beta chain; MHC class II DRB3; MHC class II leukocyte antigen BoLA-DRB3; MHC class II protein; MHC class II-associated invariant chain; MHC(BoLA) class II DR-beta chain; XXbac-BPG161M6.1

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基因别名: AI323765; BLA-DRB3; BoLA-DRB; Bota-DRB01; Bota-DRB02; Bota-DRB04; Bota-DRB07; Bota-DRB21; Bota-DRB22; CD74; CLIP; DHLAG; DRB3; E-alpha-f; H-2Ea; H2-Ea; H2-Ea-ps; HLA-DRA; HLA-DRA1; HLA-DRB1; HLA-DRB3; HLA-DRB4; HLA-DRB5; HLADG; I-Ealpha; Ia-3; Ia-GAMMA; Ia3; Ii; LA-DRB

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UniProt ID: (Mouse) P04441, (Mouse) P04224

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Entrez Gene ID: (Bovine) 506214, (Bovine) 282530, (Goat) 102185560, (Sheep) 101102561, (Bovine) 613384, (Mouse) 16149, (Mouse) 100504404

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功能
beta-amyloid binding cytokine receptor activity protein binding cytokine binding MHC class II protein complex binding macrophage migration inhibitory factor binding MHC class II protein binding MHC class II protein binding, via antigen binding groove protein binding involved in protein folding nitric-oxide synthase binding scaffold/adaptor protein major histocompatibility complex protein
参与通路
activation of MAPK activity prostaglandin biosynthetic process positive regulation of cytokine-mediated signaling pathway immune system process positive regulation of dendritic cell antigen processing and presentation negative regulation of peptide secretion positive regulation of adaptive immune response positive regulation of type 2 immune response negative regulation of mature B cell apoptotic process protein folding protein complex assembly intracellular protein transport defense response immune response signal transduction cell proliferation immunoglobulin mediated immune response cytokine-mediated signaling pathway antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II positive regulation of B cell proliferation macrophage migration inhibitory factor signaling pathway negative regulation of apoptotic process negative regulation of DNA damage response, signal transduction by p53 class mediator positive thymic T cell selection negative thymic T cell selection positive regulation of innate immune response negative regulation of T cell differentiation positive regulation of T cell differentiation positive regulation of fibroblast proliferation positive regulation of peptidyl-tyrosine phosphorylation chaperone mediated protein folding requiring cofactor positive regulation of macrophage cytokine production positive regulation of ERK1 and ERK2 cascade positive regulation of neutrophil chemotaxis negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of chemokine (C-X-C motif) ligand 2 production
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