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Invitrogen
ITGB1 Monoclonal Antibody (3B6)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-17103
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3B6
Immunogen
Purified recombinant fragment of human ITGB1 expressed in E. Coli.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-17103 targets ITGB1 in FACS, IHC, indirect ELISA, and WB applications and shows reactivity with Human and Non-human primate samples.
The MA5-17103 immunogen is purified recombinant fragment of human ITGB1 expressed in E. Coli.
MA5-17103 detects ITGB1 which has a predicted molecular weight of approximately 88.4kDa.
Target Information
CD29, also known as ITGB1 or Integrin Subunit Beta 1, is a 110 kDa cell surface glycoprotein widely expressed by various cells, including all leukocytes. It forms non-covalently linked heterodimers with at least six different alpha integrins (CD49a-f), creating VLA-1 through VLA-6 complexes, as well as with CD51. These alpha-beta integrin heterodimers mediate a range of cellular responses, including adhesion, trafficking, proliferation, and differentiation. CD29-containing integrins bind to extracellular matrix proteins such as collagen, laminin, fibronectin, and vitronectin. Some integrins also interact with cellular receptors like VCAM-1 and MadCAM-1. CD29 plays a crucial role in immune cell trafficking from blood to tissue, particularly during leukocyte emigration and extravascular migration. It is involved in regulating tissue damage and disease symptoms related to inflammatory bowel disease. In the presence of anti-tumor drugs, decreased expression of ITGB1 correlates with multidrug resistance in tumor cells. ITGB1-dependent mechanisms enhance cytokine secretion in human airway smooth muscle in response to IL-1beta, facilitated by fibronectin and type I collagen. More than eight beta subunits with numerous splice variant isoforms have been identified in mammals, including two major forms: beta1A and beta1D. Beta1A is present in all tissues except cardiac and skeletal muscle, which express the beta1D variant.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD29; Fibronectin receptor subunit beta; Glycoprotein IIa; GPIIA; Integrin beta-1; Integrin beta1; ITBG1D; VLA-4 subunit beta
Gene Aliases: 4633401G24Rik; AA409975; AA960159; CD29; ENSMUSG00000051907; FNRB; Gm9863; gpIIa; ITGB1; MDF2; MSK12
UniProt ID: (Mouse) P09055
Entrez Gene ID: (Mouse) 16412
glycoprotein binding
fibronectin binding
protease binding
actin binding
receptor activity
receptor binding
integrin binding
protein binding
collagen binding
kinase binding
protein kinase binding
protein domain specific binding
protein complex binding
peptide binding
laminin binding
metal ion binding
protein heterodimerization activity
cell adhesion molecule binding
alpha-actinin binding
collagen binding involved in cell-matrix adhesion
integrin
G1/S transition of mitotic cell cycle
in utero embryonic development
cell fate specification
tissue homeostasis
cell migration involved in sprouting angiogenesis
cellular calcium ion homeostasis
cell adhesion
leukocyte cell-cell adhesion
cell-matrix adhesion
calcium-independent cell-matrix adhesion
transforming growth factor beta receptor signaling pathway
integrin-mediated signaling pathway
regulation of G-protein coupled receptor protein signaling pathway
positive regulation of cell proliferation
negative regulation of cell proliferation
germ cell migration
visual learning
regulation of collagen catabolic process
positive regulation of cell-substrate adhesion
positive regulation of neuron projection development
cell migration
formation of radial glial scaffolds
positive regulation of cell migration
neuron projection development
negative regulation of cell projection organization
cell-substrate adhesion
protein transport within lipid bilayer
heterotypic cell-cell adhesion
negative regulation of Rho protein signal transduction
positive regulation of apoptotic process
stress fiber assembly
positive regulation of MAPK cascade
sarcomere organization
negative regulation of cell differentiation
negative regulation of neuron differentiation
positive regulation of neuron differentiation
positive regulation of endocytosis
axon extension
cardiac muscle tissue development
dendrite morphogenesis
positive regulation of peptidyl-tyrosine phosphorylation
leukocyte tethering or rolling
regulation of cell cycle
cardiac muscle cell differentiation
bicellular tight junction assembly
positive regulation of establishment of protein localization to plasma membrane
negative regulation of anoikis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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