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Invitrogen
SIAH1/SIAH2 Monoclonal Antibody (8G7H12)
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产品信息
MA5-24781
产品规格
种属反应
Fruit fly,
Human,
Mouse,
Pig,
Rat,
Zebrafish
已发表种属
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
8G7H12
抗原
Synthetic peptide made to a C-terminal portion of the drosophila SINA protein (within residues 280-331).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
Conc. Not Determined
保存液
tissue culture supernatant
内含物
0.1% sodium azide
保存条件
4°C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This is specific for human SIAH 1 and 2 and Drosophila SINA in proliferating cells and stem cells. This does not detect Drosophila SINAH or normal, nondividing cells.
Does not react with mouse.
靶标信息
SIAH, the human homologue of the Drosophila seven in absentia (sina) gene, is a tumor suppressor protein that is expressed in intestinal epithelium and activated during apoptosis. Human SIAH proteins are produced as two distinct gene products, SIAH-1, and a slightly larger protein SIAH-2, which share a highly conserved C-terminal sequence and differ in their N-terminal regions. SIAH-1 is a 32 kDa protein that contains an N-terminal RING-finger domain, which is required for proteolysis, and a cystein-rich C-terminal domain, which regulates oligomerization and SIAH binding to target proteins. As a tumor suppressor, SIAH-1 binds DCC (deleted in colorectal cancer) and regulates DCC degradation via the ubiquitin-proteasome pathway. SIAH-1 also binds a Bcl-2 related protein, Bag-1, thereby inhibiting cell growth. The majority of SIAH-1 is localized to the nucleus, however a small percentage is detected in the cytoplasm. This nuclear localization suggests that SIAH proteins may interact with other nuclear matrix proteins and DNA.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: anon-fast-evolving-2H7; CG9949-PA; CG9949-PB; CG9949-PC; E3 ubiquitin-protein ligase SIAH1; E3 ubiquitin-protein ligase SIAH2; E3 ubiquitin-protein ligase sina; EC 6.3.2; FLJ08065; HL08111p; hSIAH1; mSiah2; RING-type E3 ubiquitin transferase SIAH1; RING-type E3 ubiquitin transferase SIAH2; RING-type E3 ubiquitin transferase sina; seven in absenti; seven in absentia 1A; seven in absentia 2; Seven in absentia homolog 1; Seven in absentia homolog 2; Seven in absentia protein; seven-in-absentia; Siah-1; Siah-1a; Siah-2; sina-PA; sina-PB; sina-PC; unnamed protein product
基因别名: AA415433; anon-EST:fe2H7; BURHAS; CG9949; Dmel\CG9949; Dmel_CG9949; hSiah2; HUMSIAH; id:ibd2635; sia; SIAH; SIAH1; SIAH1A; SIAH2; SINA; Sinh2; zgc:56026
UniProt ID: (Human) Q8IUQ4, (Human) O43255, (Rat) Q920M9, (Mouse) Q06986, (Rat) Q8R4T2, (Zebrafish) Q7ZVG6, (Fruit fly) P21461
Entrez Gene ID: (Pig) 100520614, (Human) 6477, (Human) 6478, (Pig) 100622531, (Rat) 140941, (Mouse) 20439, (Rat) 140593, (Zebrafish) 80955, (Fruit fly) 39884
ubiquitin-protein transferase activity
protein binding
zinc ion binding
transferase activity
ubiquitin conjugating enzyme binding
identical protein binding
metal ion binding
ubiquitin protein ligase activity
transcription corepressor activity
protein C-terminus binding
ligase activity
protein homodimerization activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
ubiquitin-protein ligase
protein modifying enzyme
ubiquitin-dependent protein catabolic process
apoptotic process
spermatogenesis
nervous system development
axon guidance
anatomical structure morphogenesis
protein ubiquitination
cell differentiation
protein catabolic process
protein destabilization
positive regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
neuron apoptotic process
canonical Wnt signaling pathway
amyloid fibril formation
regulation of apoptotic signaling pathway
positive regulation of intrinsic apoptotic signaling pathway
small GTPase mediated signal transduction
regulation of protein ubiquitination
regulation of circadian rhythm
negative regulation of apoptotic process
negative regulation of transcription, DNA-templated
rhythmic process
negative regulation of canonical Wnt signaling pathway
negative regulation of extrinsic apoptotic signaling pathway
male meiosis I
multicellular organism development
post-embryonic development
regulation of multicellular organism growth
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
cell cycle
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
cellular protein catabolic process
sensory organ development
R7 cell fate commitment
proteasomal protein catabolic process
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
enteroendocrine cell differentiation
sevenless signaling pathway
regulation of R7 cell differentiation
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