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Invitrogen
Alpha A Crystallin Monoclonal Antibody (OTI3B12)
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Product Details
MA5-26164
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
OTI3B12
Immunogen
Full length human recombinant protein of CRYAA produced in HEK293T cell
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index of the lens. The mammalian lens contains 3 major classes of crystallins: alpha, beta, and gamma. Alpha-crystallin is the largest of the crystallins and is composed of 2 primary gene products-alpha-A and alpha-B. There are at least 5 different proteins comprising the beta-crystallins. The gamma-crystallins are monomeric, but there are at least 5 gamma crystallins identified in bovine and rat lens. Alpha-Crystallin comprises 40% of total lens protein composition. In addition to maintaining proper refractive index, it also functions in a chaperone like manner by preventing the formation of aggregates possibly leading to cataract formation. It is believed that the phosphorylated states of the alpha-crystallin occur in response to cellular stress and may serve a structural control function and play a role in protein maintenance. Alpha-B crystallin has been linked to Alexander's disease where it accumulates in brain cells of those afflicted.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Acry 1; Alpha-crystallin A chain; CRYA 1; CRYAA; Crystallin Alpha 1; crystallin, alpha-1; Heat shock protein beta-4; Heat shock protein family B member 4; HSPB 4; HspB4; human alphaA-crystallin (CRYA1)
Gene Aliases: CRYA1; CRYAA; CRYAA2; CTRCT9; HSPB4
UniProt ID: (Human) P02489
Entrez Gene ID: (Human) 1409, (Human) 102724652
response to hypoxia
lens development in camera-type eye
lens morphogenesis in camera-type eye
apoptotic process
mitochondrion organization
actin filament organization
microtubule-based process
tubulin complex assembly
visual perception
response to heat
negative regulation of gene expression
positive regulation of cell growth
negative regulation of intracellular transport
protein refolding
response to hydrogen peroxide
camera-type eye development
negative regulation of apoptotic process
embryonic camera-type eye morphogenesis
protein stabilization
apoptotic process involved in morphogenesis
response to UV-A
lens fiber cell morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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