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Invitrogen
RAB3A Monoclonal Antibody (OTI5C12)
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FIGURE: 1 / 4
RAB3A Antibody (MA5-27178) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded carcinoma of human prostate tissue. To expose target proteins, heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min. Following antigen retrieval, tissues were probed with a RAB3A monoclonal antibody (Product # MA5-27178) at a dilution of 1:150.
Product Details
MA5-27178
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI5C12
Immunogen
Full length human recombinant protein of RAB3A produced in E.coli
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Rab proteins belong to the Ras small GTPase superfamily. The GTP-binding Rab3 subfamily has 4 known isoforms: 3A, 3B, 3C, and 3D. These proteins are expressed in highest concentrations in brain and endocrine tissues and involved in regulated exocytosis of hormones and neurotransmitters. Specifically, Rab 3s are thought to play a key role in presynaptic vesicle trafficking and priming.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C18A3.6; RAS-associated protein RAB3A; Ras-related protein Rab-3A; Ras-related small GTP binding protein 3A; unnamed protein product
Gene Aliases: RAB3; RAB3A
UniProt ID: (Human) P20336, (Rat) P63012, (Mouse) P63011
Entrez Gene ID: (Human) 5864, (Rat) 25531, (Mouse) 19339
respiratory system process
intracellular protein transport
vesicle docking involved in exocytosis
mitochondrion organization
neuromuscular synaptic transmission
axonogenesis
metabolic process
protein secretion
post-embryonic development
synaptic vesicle exocytosis
synaptic vesicle maturation
regulation of exocytosis
lung development
regulation of synaptic vesicle fusion to presynaptic membrane
Rab protein signal transduction
positive regulation of ATPase activity
synaptic vesicle recycling
regulation of short-term neuronal synaptic plasticity
maintenance of presynaptic active zone structure
sensory perception of touch
response to electrical stimulus
protein localization to plasma membrane
positive regulation of regulated secretory pathway
plasma membrane repair
exocytosis
protein transport
calcium ion regulated exocytosis
insulin secretion
lysosome localization
constitutive secretory pathway
regulated exocytosis
positive regulation of exocytosis
synaptic vesicle transport
establishment of localization in cell
acrosomal vesicle exocytosis
evoked neurotransmitter secretion
synaptic vesicle clustering
regulation of presynaptic dense core granule exocytosis
regulation of plasma membrane repair
transport
small GTPase mediated signal transduction
regulation of long-term synaptic potentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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