Search
Additional Information:
{{banner.description}}
Product Details
MA5-31959
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
SA0290
Immunogen
Synthetic peptide within Human LRP1 aa 4,471-4,520.
Conjugate
Form
Liquid
Concentration
1.051 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
CD91 is a 600 kDa type I transmembrane protein composed of an alpha and beta chain. The alpha chain interacts with a variety of structurally and functionally diverse ligands, while the beta chain contains two tyrosine phosphorylation motifs that interact with adaptor and signaling proteins. This receptor is expressed by cells in the monocytic lineage, dendritic cells, hepatocytes, fibroblasts, adipocytes, neurons, and syncytiotrophoblasts. CD91 plays a crucial role in several cellular processes, including ligand endocytosis and trafficking to lysosomes, intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. It is involved in cross-presenting antigens via MHC class I molecules on antigen-presenting cells after endocytosis of heat shock protein-peptide complexes. Additionally, CD91 is essential for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of CD91 decreases with age and is found to be lower in brain tissue from Alzheimer patients compared to controls. The receptor also plays a role in cell migration and activating signaling cascades, highlighting its importance in both immune function and disease processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: A2MR; alpha 2-macroglobulin receptor; Alpha-2-macroglobulin receptor; APOER; Apolipoprotein E receptor; CD91; FLJ16451; lipoprotein receptor-related protein; low density lipoprotein receptor-related protein 1; low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor); LRP-1; lrp1; MGC88725; Prolow-density lipoprotein receptor-related protein 1; TbetaR-V/LRP-1/IGFBP-3 receptor; type V tgf-beta receptor
Gene Aliases: A2MR; AI316852; APOER; APR; b2b1554Clo; CD91; DDH3; IGFBP-3R; IGFBP3R; IGFBP3R1; KPA; LRP; LRP1; LRP1A; TGFBR5
UniProt ID: (Human) Q07954, (Mouse) Q91ZX7, (Rat) G3V928
Entrez Gene ID: (Human) 4035, (Mouse) 16971, (Rat) 299858
beta-amyloid binding
RNA binding
low-density lipoprotein receptor activity
scavenger receptor activity
calcium ion binding
protein binding
alpha-2 macroglobulin receptor activity
apolipoprotein receptor activity
clathrin heavy chain binding
apolipoprotein binding
signaling receptor activity
cargo receptor activity
heparan sulfate proteoglycan binding
macromolecular complex binding
metal ion binding
lipoprotein particle receptor binding
protease binding
protein complex binding
poly(A) RNA binding
apolipoprotein
extracellular matrix structural protein
transmembrane signal receptor
retinoid metabolic process
astrocyte activation involved in immune response
lipid metabolic process
endocytosis
receptor-mediated endocytosis
phagocytosis
lysosomal transport
enzyme linked receptor protein signaling pathway
negative regulation of macromolecule metabolic process
negative regulation of gene expression
regulation of extracellular matrix disassembly
positive regulation of cholesterol efflux
negative regulation of smooth muscle cell migration
regulation of endocytosis
negative regulation of Wnt signaling pathway
receptor internalization
positive regulation of lipid transport
regulation of actin cytoskeleton organization
aorta morphogenesis
lipoprotein transport
apoptotic cell clearance
transcytosis
positive regulation of endocytosis
positive regulation of transport
regulation of protein metabolic process
negative regulation of SMAD protein import into nucleus
beta-amyloid clearance
amyloid-beta clearance by transcytosis
amyloid-beta clearance by cellular catabolic process
transport across blood-brain barrier
positive regulation of beta-amyloid clearance
regulation of extracellular matrix organization
positive regulation of reverse cholesterol transport
positive regulation of protein localization to plasma membrane
positive regulation of transcytosis
cellular response to beta-amyloid
positive regulation of lysosomal protein catabolic process
negative regulation of platelet-derived growth factor receptor-beta signaling pathway
protein kinase C-activating G-protein coupled receptor signaling pathway
multicellular organism development
cholesterol metabolic process
cell proliferation
negative regulation of neuron projection development
regulation of cholesterol transport
regulation of phospholipase A2 activity
negative regulation of neuron apoptotic process
positive regulation of protein transport
aging
lipoprotein metabolic process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support