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Invitrogen
CD61 (Integrin beta 3) Recombinant Rabbit Monoclonal Antibody (SJ19-09)
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Product Details
MA5-32077
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
C. elegans,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
SJ19-09
Immunogen
Synthetic peptide within Human Integrin beta 3 aa 729-788
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
CD61, also known as GPIIIa or ITGB3, is a 105 kDa glycoprotein expressed on activated T cells, granulocytes, megakaryocytes, platelets, and their precursors. It plays a crucial role in platelet aggregation and functions as a receptor for fibrinogen, fibronectin, von Willebrand factor, vitronectin, and thrombospondin. CD61 forms heterodimeric complexes by associating non-covalently with integrin alpha subunits: alphaV (CD51) to create the Vitronectin Receptor and alphaIIb (CD41) to form gpIIb/IIIa. These complexes are responsible for adhesion to extracellular matrix components, facilitating cell adhesion and cell-surface mediated signaling. CD61 is expressed on platelets and megakaryocytes in association with CD41, and on endothelial cells, monocytes, and osteoclasts in association with CD51. The protein product of CD61 is composed of an alpha chain and a beta chain, which can combine with multiple partners to form different integrins. Its involvement in cell adhesion and signaling underscores its importance in normal physiological processes. Dysfunction of CD61 is associated with diseases such as Glanzmann Thrombasthenia and Platelet type-16 Bleeding Disorder, highlighting its critical role in hemostasis and platelet function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: antigen CD61; CD61; GPIIIa; integrin beta 3; Integrin beta-3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); platelet gpIIIa; Platelet membrane glycoprotein IIIa
Gene Aliases: BDPLT16; BDPLT2; CD61; GP3A; GPIIIa; GT; INGRB3; ITGB3
UniProt ID: (Human) P05106, (Mouse) O54890
Entrez Gene ID: (Human) 3690, (Mouse) 16416
virus receptor activity
fibronectin binding
protease binding
protein disulfide isomerase activity
platelet-derived growth factor receptor binding
protein binding
coreceptor activity
fibroblast growth factor binding
enzyme binding
C-X3-C chemokine binding
insulin-like growth factor I binding
neuregulin binding
identical protein binding
vascular endothelial growth factor receptor 2 binding
cell adhesion molecule binding
extracellular matrix binding
receptor activity
integrin binding
peptide binding
fibrinogen binding
integrin
positive regulation of protein phosphorylation
positive regulation of endothelial cell proliferation
platelet degranulation
cell-substrate junction assembly
cell adhesion
cell-matrix adhesion
integrin-mediated signaling pathway
blood coagulation
positive regulation of endothelial cell migration
negative regulation of macrophage derived foam cell differentiation
negative regulation of lipid storage
smooth muscle cell migration
cell growth
cell migration
platelet activation
extracellular matrix organization
positive regulation of vascular endothelial growth factor receptor signaling pathway
cell-substrate adhesion
activation of protein kinase activity
negative regulation of lipid transport
heterotypic cell-cell adhesion
substrate adhesion-dependent cell spreading
tube development
apolipoprotein A-I-mediated signaling pathway
wound healing
regulation of bone resorption
negative regulation of low-density lipoprotein particle receptor biosynthetic process
viral entry into host cell
vascular endothelial growth factor receptor signaling pathway
mesodermal cell differentiation
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of lipoprotein metabolic process
leukocyte migration
negative chemotaxis
angiogenesis involved in wound healing
platelet aggregation
positive regulation of leukocyte migration
protein folding
cellular calcium ion homeostasis
regulation of G-protein coupled receptor protein signaling pathway
positive regulation of fibroblast migration
positive regulation of smooth muscle cell migration
regulation of cell migration
positive regulation of cell migration
positive regulation of cell adhesion mediated by integrin
positive regulation of osteoblast proliferation
positive regulation of MAPK cascade
positive regulation of osteoclast differentiation
positive regulation of angiogenesis
positive regulation of bone resorption
positive regulation of smooth muscle cell proliferation
cell projection morphogenesis
regulation of release of sequestered calcium ion into cytosol
negative regulation of cell death
positive regulation of ERK1 and ERK2 cascade
positive regulation of glomerular mesangial cell proliferation
positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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