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Invitrogen
ERCC1 Recombinant Rabbit Monoclonal Antibody (JM10-07)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-32580
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JM10-07
抗原
Recombinant protein within Human ERCC1 aa 1-220.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
ERCC1 is a non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. It is responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). It participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. ERCC1 is also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4. (Uniprot)
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DNA excision repair protein ERCC-1
基因别名: Ercc-1; ERCC1
UniProt ID: (Mouse) P07903
Entrez Gene ID: (Mouse) 13870
single-stranded DNA endodeoxyribonuclease activity
TFIID-class transcription factor binding
DNA binding
damaged DNA binding
single-stranded DNA binding
nuclease activity
endonuclease activity
protein binding
protein C-terminus binding
hydrolase activity
TBP-class protein binding
protein domain specific binding
structure-specific DNA binding
endodeoxyribonuclease
pyrimidine dimer repair by nucleotide-excision repair
replicative cell aging
DNA repair
nucleotide-excision repair
nucleotide-excision repair, DNA incision, 3'-to lesion
nucleotide-excision repair, DNA incision, 5'-to lesion
double-strand break repair
DNA recombination
mitotic recombination
syncytium formation
cellular response to DNA damage stimulus
response to oxidative stress
germ cell development
spermatogenesis
cell proliferation
male gonad development
UV protection
response to X-ray
multicellular organism aging
negative regulation of telomere maintenance
post-embryonic hemopoiesis
multicellular organism growth
interstrand cross-link repair
isotype switching
cell development
oogenesis
chromosome organization
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