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Invitrogen
NOTCH4 Recombinant Rabbit Monoclonal Antibody (JM101-05)
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Product Details
MA5-32581
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JM101-05
Immunogen
Synthetic peptide within Human NOTCH4 aa 1920-1960.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases (entrez gene).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DAQB-143M3.4; FLJ16302; hNotch4; human homolog of Drosophila Notch; MGC74442; Neurogenic locus notch homolog protein 4; Notch 4; Notch gene homolog 4; Notch homolog 4; NOTCH3; unnamed protein product
Gene Aliases: Int-3; INT3; N4; NOTCH4
UniProt ID: (Human) Q99466, (Mouse) P31695
Entrez Gene ID: (Human) 4855, (Mouse) 18132
negative regulation of transcription from RNA polymerase II promoter
luteolysis
patterning of blood vessels
cell fate determination
morphogenesis of a branching structure
epithelial to mesenchymal transition
endothelial cell morphogenesis
vasculature development
regulation of transcription, DNA-templated
Notch signaling pathway
positive regulation of transcription of Notch receptor target
tissue development
hemopoiesis
cell differentiation
mammary gland development
endothelial cell differentiation
regulation of cell differentiation
negative regulation of cell differentiation
negative regulation of endothelial cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cell development
regulation of developmental process
positive regulation of developmental process
positive regulation of smooth muscle cell differentiation
negative regulation of cell adhesion molecule production
negative regulation of cell-cell adhesion mediated by cadherin
transcription, DNA-templated
multicellular organism development
regulation of Notch signaling pathway
embryo development
regulation of protein localization
negative regulation of Notch signaling pathway
positive regulation of angiogenesis
regulation of protein processing
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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