Invitrogen

HLA-DPB1 Recombinant Rabbit Monoclonal Antibody (JA10-94)

Name: HLA-DPB1 Recombinant Rabbit Monoclonal Antibody (JA10-94)
Brand: Invitrogen
SKU: MA5-32660

查看其他11个HLA-DPB1抗体

说明书

证书

实验方案

问题与答案

技术支持

说明书

证书

实验方案

问题与答案

技术支持

说明书

证书

实验方案

问题与答案

技术支持

Additional Information:

抗体检测数据 (2)

HLA-DPB1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 2

HLA-DPB1 Antibody (MA5-32660) in IHC (P)

Immunohistochemical analysis of HLA-DPB1 of paraffin-embedded Human spleen tissue using a HLA-DPB1 Monoclonal antibody (Product #MA5-32660). Counter stained with hematoxylin.

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Immunogen image

Immunogen Image HLA-DPB1 Recombinant Rabbit Monoclonal Antibody (JA10-94)

产品信息

MA5-32660

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

免疫组化（石蜡） (IHC (P))

1:50-1:200

免疫细胞化学 (ICC/IF)

1:50-1:100

免疫沉淀 (IP)

1:10-1:50

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

JA10-94

抗原

Synthetic peptide within Human HLA-DPB1 aa 11-60.

3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

100 µg

纯化类型

Protein A

保存液

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2809937

产品详细信息

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

靶标信息

HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: DP beta 1 domain protein; HLA class II histocompatibility antigen, DP beta 1 chain; HLA class II histocompatibility antigen, DP(W4) beta chain; HLA DP4 beta-chain; HLA-DP histocompatibility type, beta-1 subunit; light chain; MHC cla; MHC class II antigen DPB1; MHC class II HLA-DP-beta-1; MHC HLA DPB1; MHC HLA-DPw4b-beta chain precursor; MHC HLA-SB-beta chain I; SB-beta chain; unnamed protein product

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基因别名: DPB1; HLA-DP; HLA-DP1B; HLA-DPB; HLA-DPB1

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UniProt ID: (Human) P79608

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Entrez Gene ID: (Human) 3115

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功能

protein binding MHC class II protein complex binding peptide antigen binding

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