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Invitrogen
PMP22 Recombinant Rabbit Monoclonal Antibody (JM52-30)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-32726
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JM52-30
Immunogen
Synthetic peptide within Human PMP22 aa 1-50.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
Peripheral Myelin Protein 22 (PMP22) is a 160 amino acid glycoprotein which is a member of the claudin family and is thought to play an important role in the structure of peripheral nerve myelin. Irregularities in its gene results in hereditary demyelinating neuropathies. PMP22 protein is present in the compact myelin of adult human peripheral nerve and its distribution mimics that of Myelin Protein zero (P0).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD25; Charcot-Marie-Tooth neuropathy 1A (greatly reduced nerve conduction velocity, hereditary motor sensory neuropathy Ia); growth arrest-specific protein 3; growth-arrest-specific Gas-3 homolog; peripheral myelin; peripheral myelin protein 22 kDa; PMP-22; PMP22; SAG; schwann cell membrane glycoprotein; SR13 myelin protein; unnamed protein product
Gene Aliases: CIDP; CMT1A; CMT1E; DSS; GAS-3; GAS3; HMSNIA; HNPP; Sp110
UniProt ID: (Human) Q01453, (Rat) P25094
Entrez Gene ID: (Human) 5376, (Rat) 24660
lipid metabolic process
autophagy
apoptotic process
immune response
cell adhesion
nervous system development
peripheral nervous system development
mating
adult walking behavior
cholesterol metabolic process
negative regulation of cell proliferation
adult locomotory behavior
response to bacterium
regulation of gene expression
proteasomal protein catabolic process
regulation of Schwann cell proliferation
positive regulation of gene expression
negative regulation of gene expression
fibroblast migration
negative regulation of neuron projection development
Schwann cell differentiation
Schwann cell development
transmission of nerve impulse
neuronal action potential propagation
neuronal action potential
myelination in peripheral nervous system
lamellipodium assembly
actin cytoskeleton organization
cell differentiation
paranodal junction assembly
membrane raft organization
bleb assembly
myelin assembly
regulation of glial cell apoptotic process
cellular response to heat
cellular response to unfolded protein
response to endoplasmic reticulum stress
multicellular organism growth
Schwann cell migration
gliogenesis
myelination
proteasome-mediated ubiquitin-dependent protein catabolic process
neuronal ion channel clustering
peripheral nervous system neuron axonogenesis
regulation of inflammatory response
neuromuscular process
striated muscle cell differentiation
muscle cell development
vestibular reflex
axon development
motor behavior
aggresome assembly
basement membrane organization
neuromuscular junction development, skeletal muscle fiber
regulation of apoptotic signaling pathway
chemical synaptic transmission
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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