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Invitrogen
HDAC9 Recombinant Rabbit Monoclonal Antibody (3L5E5)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-35351
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
3L5E5
抗原
Synthetic peptide.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.6 mg/mL
规格
160 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MHSMISSVDV KSEVPVGLEP ISPLDLRTDL RMMMPVVDPV VREKQLQQEL LLIQQQQQIQ KQLLIAEFQK QHENLTRQHQ AQLQEHIKEL LAIKQQQELL
靶标信息
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is a critical component of transcriptional regulation and the acetylation of nucleosomal histones is a major source of this remodeling. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Several mammalian proteins function as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Conversely, the deacetylation of histones is associated with transcriptional silencing. The histone deacetylases (HDAC) include HDAC1-9. HDAC9 and HDAC9a are two alternatively spliced isoforms of HDAC9. HDAC9a is 132 amino acids shorter than HDAC9, but both isoforms contain the HDAC catalytic domain, remain capable of deacetylase activity and repress myoctye enhancer-binding factor 2-mediated transcription. HDAC9 and HDAC9a are expressed in brain, skeletal muscle, kidney, placenta and pancreas.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp779K1053; HD7; HD9; hdac-9; Histone deacetylase 7B; Histone deacetylase 9; Histone deacetylase-related protein; MEF2-interacting transcription repressor MITR
基因别名: HDAC7; HDAC7B; HDAC9; HDRP; KIAA0744; MITR; RGD1310748; RGD1563092
Entrez Gene ID: (Rat) 687001
molecular_function
transcription corepressor activity
histone deacetylase activity
protein kinase C binding
transcription factor binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
protein deacetylase activity
histone deacetylase binding
metal ion binding
NAD-dependent histone deacetylase activity (H3-K9 specific)
NAD-dependent histone deacetylase activity (H4-K16 specific)
repressing transcription factor binding
NAD-dependent histone deacetylase activity (H3-K18 specific)
histone modifying enzyme
negative regulation of transcription from RNA polymerase II promoter
response to amphetamine
transcription, DNA-templated
heart development
biological_process
histone deacetylation
neuron differentiation
cellular response to insulin stimulus
peptidyl-lysine deacetylation
negative regulation of transcription, DNA-templated
regulation of skeletal muscle fiber development
regulation of striated muscle cell differentiation
histone H3-K9 modification
histone H3 deacetylation
histone H4 deacetylation
positive regulation of cell migration involved in sprouting angiogenesis
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