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Invitrogen
RAPGEF3 Recombinant Rabbit Monoclonal Antibody (5A7K7)
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RAPGEF3 Antibody (MA5-35451) in IHC (P)
Immunohistochemistry analysis of RAPGEF3 in paraffin-embedded human placenta. Samples were incubated with RAPGEF3 Monoclonal antibody (Product # MA5-35451) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-35451
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
5A7K7
抗原
A synthetic peptide corresponding to a sequence within amino acids 824-923 of human Epac1/RAPGEF3 (O95398)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: FIHEGNHTLV ENLINFEKMR MMARAARMLH HCRSHNPVPL SPLRSRVSHL HEDSQVARIS TCSEQSLSTR SPASTWAYVQ QLKVIDNQRE LSRLSRELEP
靶标信息
Gene ontology (GO) annotation includes small GTPase mediated signal transduction. Target protein binds cAMP and activates the Ras superfamily guanine nucleotide binding protein (Rap1A)in a PKA-independent manner.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cAMP-GEFI; cAMP-regulated guanine nucleotide exchange factor I; cAMP-regulated guanine nucleotide exchange factor I (cAMP-GEFI); EPAC 1; Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; MGC21410; Rap guanine nucleotide exchange factor 3; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP
基因别名: 2310016P22Rik; 9330170P05Rik; CGEF1; EPAC; EPAC1; RAPGEF3
UniProt ID: (Rat) Q9Z1C8, (Mouse) Q8VCC8
Entrez Gene ID: (Rat) 59326, (Mouse) 223864
angiogenesis
Rap protein signal transduction
positive regulation of peptidyl-serine phosphorylation
negative regulation of syncytium formation by plasma membrane fusion
positive regulation of GTPase activity
positive regulation of angiogenesis
regulation of protein kinase activity
positive regulation of protein export from nucleus
positive regulation of stress fiber assembly
positive regulation of syncytium formation by plasma membrane fusion
establishment of endothelial barrier
cellular response to cAMP
positive regulation of protein acetylation
regulation of actin cytoskeleton reorganization
regulation of histone H3-K9 acetylation
regulation of protein phosphorylation
positive regulation of protein phosphorylation
small GTPase mediated signal transduction
positive regulation of smooth muscle cell migration
positive regulation of ATPase activity
negative regulation of collagen biosynthetic process
intracellular signal transduction
positive regulation of cell size
positive regulation of transcription from RNA polymerase II promoter
positive regulation of binding
positive regulation of calcium ion transport
negative regulation of cell death
positive regulation of actin cytoskeleton reorganization
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