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Invitrogen
VAMP2 Recombinant Rabbit Monoclonal Antibody (8X9D9)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-35469
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
8X9D9
Immunogen
Synthetic peptide
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.6 mg/mL
Amount
60 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MSATAATAPP AAPAGEGGPP APPPNLTSNR RLQQTQAQVD EVVDIMRVNV DKVLERDQKL SELDDRADAL QAGASQFETS AAKLKRKYWW KNLKMMIILG
Target Information
The vesicle associated membrane proteins (VAMP) or synaptobrevins are calcium binding proteins specific to eukaryotes. VAMPs, along with synaptosomal associated protein of 25 kDa (SNAP-25) and syntaxin, form the core complex of soluble NSF attachment protein receptor (SNARE) proteins that interact with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and alpha-SNAP. These membrane associated proteins play a key role in the regulation of vesicle membrane fusion with the plasma membrane. The Clostridium tetani neurotoxin is a metalloprotease with specificity for VAMP. In Alzheimer's disease, VAMP levels of all isoforms appear to be significantly lowered. It is suggested that VAMP-2 is a resident protein of the insulin-sensitive glucose transporter type 4 (GLUT4) compartment and that it is required for GLUT4 vesicle incorporation into the cell surface in response to insulin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Synaptobrevin; synaptobrevin 2; Synaptobrevin 2 (vesicle-associated membrane protein VAMP-2); synaptobrevin II; synaptobrevin-2; unnamed protein product; vamp; VAMP-2; vesicle associated membrane protein VAMP-2; vesicle-associated membrane 2; Vesicle-associated membrane protein (synaptobrevin 2)
Gene Aliases: NEDHAHM; RATVAMPB; RATVAMPIR; SYB; Syb-2; SYB2; sybII; VAMP-2
UniProt ID: (Human) P63027, (Mouse) P63044, (Rat) P63045
Entrez Gene ID: (Human) 6844, (Mouse) 22318, (Rat) 24803
exocytosis
vesicle fusion
neurotransmitter secretion
response to glucose
protein transport
synaptic vesicle exocytosis
vesicle-mediated transport
calcium ion regulated exocytosis
regulation of exocytosis
cellular response to insulin stimulus
SNARE complex assembly
Golgi to plasma membrane protein transport
eosinophil degranulation
neutrophil degranulation
natural killer cell degranulation
synaptic vesicle endocytosis
long-term synaptic potentiation
regulation of vesicle-mediated transport
membrane fusion
protein-containing complex assembly
mucus secretion
positive regulation of intracellular protein transport
regulation of delayed rectifier potassium channel activity
regulation of histamine secretion by mast cell
regulation of calcium ion-dependent exocytosis
regulated exocytosis
hormone secretion
response to cholesterol
clathrin-mediated endocytosis
exocytic insertion of neurotransmitter receptor to postsynaptic membrane
regulation of synaptic vesicle recycling
synaptic vesicle fusion to presynaptic active zone membrane
calcium-dependent activation of synaptic vesicle fusion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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