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Invitrogen
MCM4 Recombinant Rabbit Monoclonal Antibody (5N0X3)
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MCM4 Antibody (MA5-35785) in WB
Western blot analysis of MCM4 in extracts of various cell lines. Samples were incubated with MCM4 Monoclonal antibody (Product # MA5-35785) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-35785
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
5N0X3
抗原
A synthetic peptide corresponding to a sequence within amino acids 764-863 of human MCM4 (P33991)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.88 mg/mL
规格
88 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: LHREALKQSA TDPRTGIVDI SILTTGMSAT SRKRKEELAE ALKKLILSKG KTPALKYQQL FEDIRGQSDI AITKDMFEEA LRALADDDFL TVTGKTVRLL
靶标信息
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CDC21 homolog; DNA replication licensing factor MCM4; mini chromosome maintenance deficient 4 homolog; minichromosome maintenance deficient 4 homolog; P1-CDC21
基因别名: 19G; AI325074; AU045576; CDC21; mcdc21; MCM4; Mcmd4; mKIAA4003
UniProt ID: (Mouse) P49717
Entrez Gene ID: (Rat) 29728, (Mouse) 17217
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