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Invitrogen
CaMKII Pan Recombinant Rabbit Monoclonal Antibody (9P2E2)
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图: 1 / 5
CaMKII Pan Antibody (MA5-37813) in IHC (P)
Immunohistochemistry analysis of CaMKII Pan in paraffin-embedded mouse spinal cord. Samples were incubated with CaMKII Pan Monoclonal antibody (Product # MA5-37813) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-37813
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
9P2E2
抗原
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human CaMKII (NP_7419601)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.8 mg/mL
规格
80 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.05% ProClin 300
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: Mouse brain, Rat brain, C6, SH-SY5Y, U-251MG
Immunogen sequence: GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT VTPEAKDLIN KMLTINPSKR ITAAEALKHP WISHRSTVAS CMHRQETVDC LKKFNARRKL K
靶标信息
The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is an ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+/calmodulin (CaM) binding and autophosphorylation and has been implicated in regulation of the cell cycle and transcription. It is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: alpha CaM kinase II; alpha-CaMKII; Ca++/calmodulin-dependent protein kinase 2 delta subunit; Ca++/calmodulin-dependent protein kinase II beta subunit; Ca++/calmodulin-dependent protein kinase II delta subunit; Ca++/calmodulin-dependent protein kinase II, delta subunit; Ca2+/calmodulin-dependent protein kinase II; Ca2+/calmodulin-dependent protein kinase II alpha; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta; calcium/calmodulin-dependent protein kinase (CaM kinase) II delta; calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma; calcium/calmodulin-dependent protein kinase II alpha subunit; calcium/calmodulin-dependent protein kinase type II alpha chain; calcium/calmodulin-dependent protein kinase type II beta chain; calcium/calmodulin-dependent protein kinase type II delta chain; calcium/calmodulin-dependent protein kinase type II gamma chain; Calcium/calmodulin-dependent protein kinase type II subunit alpha; Calcium/calmodulin-dependent protein kinase type II subunit beta; Calcium/calmodulin-dependent protein kinase type II subunit delta; Calcium/calmodulin-dependent protein kinase type II subunit gamma; CaM kinase II subunit alpha; CaM kinase II subunit beta; CaM kinase II subunit delta; CaM kinase II subunit gamma; caM-kinase II alpha chain; caM-kinase II beta chain; caM-kinase II delta chain; caM-kinase II gamma chain; CaMK II; caMK-II subunit alpha; caMK-II subunit beta; caMK-II subunit delta; caMK-II subunit gamma
基因别名: 2810011D23Rik; 8030469K03Rik; [d]-CaMKII; CAM2; CAMK; CaMK II; CAMK-II; CAMK1; CAMK2; CAMK2A; CAMK2B; CAMK2D; CAMK2G; CAMKA; CAMKB; CAMKD; CAMKG; Camki; CaMKII; Ck2b; KIAA0968; Kiaa4163; mKIAA0968; PK2CDD; PKCCD; R74975; RATCAMKI
UniProt ID: (Mouse) P11798, (Rat) P11275, (Rat) P08413, (Mouse) P28652, (Rat) P15791, (Mouse) Q6PHZ2, (Mouse) Q923T9, (Rat) P11730
Entrez Gene ID: (Mouse) 12322, (Rat) 25400, (Rat) 24245, (Mouse) 12323, (Rat) 24246, (Mouse) 108058, (Mouse) 12325, (Rat) 171140
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
calmodulin-dependent protein kinase activity
protein binding
calmodulin binding
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
GTPase activating protein binding
glutamate receptor binding
protein homodimerization activity
phospholipase binding
sodium channel inhibitor activity
titin binding
ion channel binding
nitric-oxide synthase binding
non-receptor serine/threonine protein kinase
G1/S transition of mitotic cell cycle
response to ischemia
protein phosphorylation
calcium ion transport
positive regulation of cardiac muscle cell apoptotic process
phosphorylation
peptidyl-serine phosphorylation
ionotropic glutamate receptor signaling pathway
angiotensin-activated signaling pathway
protein autophosphorylation
regulation of neurotransmitter secretion
regulation of neuronal synaptic plasticity
positive regulation of NF-kappaB transcription factor activity
positive regulation of calcium ion transport
regulation of mitochondrial membrane permeability involved in apoptotic process
inhibitory G-protein coupled receptor phosphorylation
positive regulation of neuron projection development
regulation of synaptic transmission, cholinergic
positive regulation of phospholipase A2 activity
response to cadmium ion
regulation of long-term neuronal synaptic plasticity
cell projection morphogenesis
neuromuscular process controlling balance
long-term synaptic potentiation
activation of meiosis involved in egg activation
positive regulation of dendritic spine morphogenesis
positive regulation of synapse maturation
positive regulation of apoptotic signaling pathway
nervous system development
cell differentiation
response to hypoxia
regulation of sodium ion transport
regulation of membrane depolarization
regulation of G2/M transition of mitotic cell cycle
positive regulation of cardiac muscle hypertrophy
regulation of cell communication by electrical coupling
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
positive regulation of smooth muscle cell migration
peptidyl-threonine phosphorylation
cellular potassium ion homeostasis
endoplasmic reticulum calcium ion homeostasis
positive regulation of Rac protein signal transduction
positive regulation of smooth muscle cell proliferation
protein oligomerization
relaxation of cardiac muscle
cardiac muscle contraction
regulation of cellular localization
cell growth involved in cardiac muscle cell development
positive regulation of ERK1 and ERK2 cascade
cardiac muscle cell contraction
regulation of cardiac muscle cell action potential
regulation of cardiac muscle cell action potential involved in regulation of contraction
regulation of cell communication by electrical coupling involved in cardiac conduction
regulation of relaxation of cardiac muscle
negative regulation of sodium ion transmembrane transport
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
negative regulation of sodium ion transmembrane transporter activity
response to oxidative stress
multicellular organism development
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