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Invitrogen
XPD Recombinant Rabbit Monoclonal Antibody (6T9K6)
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图: 1 / 4
XPD Antibody (MA5-37877) in IHC (P)
Immunohistochemistry analysis of XPD in paraffin-embedded human colon carcinoma. Samples were incubated with XPD Monoclonal antibody (Product # MA5-37877) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-37877
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
6T9K6
抗原
A synthetic peptide corresponding to a sequence within amino acids 600-700 of human XPD/ERCC2 (P18074)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
50 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: HeLa, 293T, A-549
Immunogen sequence: ARGKVSEGID FVHHYGRAVI MFGVPYVYTQ SRILKARLEY LRDQFQIREN DFLTFDAMRH AAQCVGRAIR GKTDYGLMVF ADKRFARGDK RGKLPRWIQE H
靶标信息
XPD is involved with the nucleotide excision repair pathway that is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Basic transcription factor 2 80 kDa subunit; BTF2 p80; CXPD; DNA 5'-3' helicase XPD; DNA excision repair protein ERCC-2; DNA repair protein complementing XP-D cells; excision repair cross-complementing rodent repair deficiency, complementation group 2; General transcription and DNA repair factor IIH helicase subunit XPD; MGC102762; MGC126218; MGC126219; TFIIH 80 kDa subunit; TFIIH basal transcription factor complex 80 kDa subunit; TFIIH basal transcription factor complex helicase subunit; TFIIH basal transcription factor complex helicase XPD subunit; TFIIH subunit XPD; Xeroderma pigmentosum group D-complementing protein
基因别名: AA407812; AU020867; AW240756; CXPD; Ercc-2; ERCC2; XPD; XPDC
UniProt ID: (Mouse) O08811
Entrez Gene ID: (Mouse) 13871, (Rat) 308415
nucleotide binding
nucleic acid binding
DNA binding
ATP-dependent DNA helicase activity
helicase activity
protein kinase activity
ATP binding
protein C-terminus binding
ATP-dependent helicase activity
DNA-dependent ATPase activity
RNA polymerase II carboxy-terminal domain kinase activity
hydrolase activity
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
5'-3' DNA helicase activity
metal ion binding
protein N-terminus binding
iron-sulfur cluster binding
4 iron, 4 sulfur cluster binding
molecular_function
DNA helicase
in utero embryonic development
nucleobase-containing compound metabolic process
DNA repair
transcription-coupled nucleotide-excision repair
nucleotide-excision repair
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
protein phosphorylation
apoptotic process
cellular response to DNA damage stimulus
response to oxidative stress
chromosome segregation
aging
cell proliferation
response to UV
UV protection
post-embryonic development
spinal cord development
hair cycle process
extracellular matrix organization
bone mineralization
central nervous system myelin formation
DNA duplex unwinding
nucleotide-excision repair, DNA incision
multicellular organism growth
hair cell differentiation
embryonic cleavage
erythrocyte maturation
positive regulation of DNA binding
skin development
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
hair follicle maturation
hematopoietic stem cell differentiation
regulation of mitotic cell cycle phase transition
response to hypoxia
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