Search
Invitrogen
Calsequestrin Recombinant Rabbit Monoclonal Antibody (5P6U2)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-37936
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
5P6U2
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 100-200 of human Calsequestrin 1 (NP_0012223)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.3 mg/mL
Amount
130 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: Rat heart
Immunogen sequence: EDKGVGFGLV DSEKDAAVAK KLGLTEVDSM YVFKGDEVIE YDGEFSADTI VEFLLDVLED PVELIEGERE LQAFENIEDE IKLIGYFKSK DSEHYKAFED A
Target Information
The sarcoplasmic reticulum (SR) is, in part, responsible for maintaining the level of intracellular calcium in cardiac and skeletal muscle by storing and releasing calcium. Several intralumenal SR calcium binding proteins have been identified, the most prominent of these is calsequestrin. Calsequstrin is a calcium binding protein known to sequester calcium accumulated in the sarcoplasmic reticulum of muscle cells during relaxation and is found discretely localized to the junctional and corbular (terminal cisternae) SR. Calsequestrin functions to localize calcium near the junctional face of the terminal cisternae from which calcium can be released into the cytosol via the ryanodine receptor. This protein is highly acidic and has a large capacity and moderate to low affinity for calcium.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Aspartactin; calmitine; calsequestrin 1 (fast-twitch, skeletal muscle); Laminin-binding protein; unnamed protein product
Gene Aliases: CSQ; CSQ-1; CSQ1; sCSQ
UniProt ID: (Rat) P19633, (Mouse) O09165
Entrez Gene ID: (Rat) 686019, (Mouse) 12372
endoplasmic reticulum organization
skeletal muscle tissue development
response to heat
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
response to muscle inactivity
response to denervation involved in regulation of muscle adaptation
sarcomere organization
protein polymerization
positive regulation of release of sequestered calcium ion into cytosol
regulation of muscle system process
positive regulation of store-operated calcium channel activity
regulation of store-operated calcium entry
regulation of muscle contraction
regulation of striated muscle contraction
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support