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Invitrogen
4-1BB Ligand Recombinant Rabbit Monoclonal Antibody (8E5D6)
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4-1BB Ligand Antibody (MA5-38063) in WB
Western blot was performed using Anti-4-1BB Ligand Recombinant Rabbit Monoclonal Antibody (ARC1963) (Product # MA5-38063) and 27 and 30 kDa bands corresponding to 4-1BBL/CD137 Ligand/TNFSF9 were observed across cell lines tested except Hep G2. Whole cell extracts (30 µg lysate) of Raji (Lane 1), Raji treated with PMA (Lane 2), THP-1 (Lane 3), HeLa (Lane 4), MOLT-4 (Lane 5), IMR-32 (Lane 6), HEL 92.1.7 (Lane 7) and Hep G2 (Lane 8) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0321BOX), 10 well. Resolved proteins... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-38063
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
8E5D6
抗原
Synthetic peptide
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.8 mg/mL
规格
80 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: HeLa, Raji, SH-SY5Y, Mouse lung, Mouse brain, Rat lung
Immunogen sequence: GEGSGSVSLA LHLQPLRSAA GAAALALTVD LPPASSEARN SAFGFQGRLL HLSAGQRLGV HLHTEARARH AWQLTQGATV LGLFRVTPEI PAGLPSPRSE
靶标信息
CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily. CD137L is a co-stimulatory molecule that is expressed on antigen presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation. Its receptor, CD137/4-1BB, is found on a variety of cells, including inflamed endothelial cells, where its expression enhances extravasation of CD137L expressing monocytes. Activated T cells also express CD137, and engagement with CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity. CD137L is also expressed on a majority of B-cell lymphomas, including mantle cell lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma (but it is lacking on Hodgkin lymphoma and T-cell lymphoma). CD137L is also expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interactions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 4 1 BB Ligand; 4 1 BBL; 4-1BB ligand; 4-1BBL; 41BB Ligand; 41BBL; CD 137 Ligand; CD 137L; CD137 Ligand; CDw137L; costimulatory molecule; TNFRSF9; Tumor necrosis factor ligand superfamily member 9
基因别名: 4-1BB-L; 4-1BBL; AI848817; Cd137l; Cd157l; Ly63l; TNFSF9
UniProt ID: (Mouse) P41274
Entrez Gene ID: (Mouse) 21950, (Rat) 353218
immune response
cell-cell signaling
positive regulation of interferon-gamma production
positive regulation of interleukin-12 production
positive regulation of interleukin-6 production
positive regulation of activated T cell proliferation
regulation of cell proliferation
myeloid dendritic cell differentiation
positive regulation of cytotoxic T cell differentiation
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