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Invitrogen
AGTR2 Recombinant Rabbit Monoclonal Antibody (6C7)
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AGTR2 Antibody (MA5-38402) in WB
Western Blot analysis of AGTR2 using AGTR2 Monoclonal Antibody (Product # MA5-38402) at 1:2,000. Positive WB detected in: 293T whole cell lysate, HepG2 whole cell lysate, A549 whole cell lysate, MCF-7 whole cell lysate, Jurkat whole cell lysate, Mouse liver tissue, Mouse heart tissue. Secondary: Goat polyclonal to rabbit IgG at 1:50,000 dilution. Predicted band size: 42 kDa. Observed band size: 42 kDa
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-38402
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
6C7
抗原
A synthesized peptide derived from human AGTR2
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.33 mg/mL
规格
33 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody has been tested in direct-ELISA
靶标信息
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion that acts through at least two types of receptors, AGTR1 and AGTR2. It is an important effector controlling blood pressure and volume in the cardiovascular system and plays a major role in the development of the mammalian kidney and urinary tract. Like AGTR1, AGTR2 is a seven transmembrane G protein-coupled receptor (GPCR), but AGTR2 does not demonstrate most of the classic features of GPCR signaling. AGTR2 is involved in a wide range of activities, including the induction of neurite outgrowth and the inhibition of cellular proliferation, in addition to the known function of mediation of vasoconstriction.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Angiotensin ii at2; Angiotensin II type-2 receptor; AT2 receptor; Type-2 angiotensin II receptor
基因别名: AGTR2; AI316812; AW107640
UniProt ID: (Mouse) P35374
Entrez Gene ID: (Mouse) 11609
regulation of systemic arterial blood pressure by circulatory renin-angiotensin
renin-angiotensin regulation of aldosterone production
vasodilation by angiotensin involved in regulation of systemic arterial blood pressure
brain renin-angiotensin system
cellular sodium ion homeostasis
inflammatory response
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
positive regulation of cell proliferation
negative regulation of heart rate
negative regulation of norepinephrine secretion
cerebellar cortex development
negative regulation of icosanoid secretion
positive regulation of phosphoprotein phosphatase activity
intracellular signal transduction
regulation of metanephros size
exploration behavior
positive regulation of renal sodium excretion
aldosterone secretion
angiotensin-activated signaling pathway
regulation of vasodilation
dopamine biosynthetic process
regulation of apoptotic process
regulation of transcription factor import into nucleus
negative regulation of neuron apoptotic process
positive regulation of transcription, DNA-templated
positive regulation of vasodilation
negative regulation of fibroblast proliferation
positive regulation of cytokine secretion
positive regulation of nitric-oxide synthase activity
negative regulation of neurotrophin TRK receptor signaling pathway
kidney morphogenesis
cell growth involved in cardiac muscle cell development
cellular response to dexamethasone stimulus
positive regulation of metanephric glomerulus development
positive regulation of branching involved in ureteric bud morphogenesis
positive regulation of extrinsic apoptotic signaling pathway
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