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Invitrogen
BRG1 Recombinant Rabbit Monoclonal Antibody (SN20-03)
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图: 1 / 14
BRG1 Antibody (MA5-41176) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of BRG1 in RH-35 cells (green). Formalin fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 10 minutes at room temperature and blocked with 1% Blocker BSA for 15 minutes at room temperature. Cells were probed with BRG1 Recombinant Monoclonal Antibody (Product # MA5-41176) at a dilution of 1:50 for 1 hour at room temperature, washed with PBS. Alexa Fluor®488 Goat anti-Rabbit IgG was used as the secondary antibody at 1:1,000 dilution. The nuclear counter stain is DAPI (blue).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-41176
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
SN20-03
抗原
Synthetic peptide within human BRG1 aa 240-280.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
TBS, pH 7.4, with 40% glycerol, 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Brg1 (Brahma-related gene 1) is an ATPase subunit of SWI2/SNF2-like chromatin-remodeling complexes that enable access of regulatory and effector proteins in transcription, DNA repair and DNA replication. Although Brg1-containing complexes are not essential for general cell survival, they participate in transcriptional regulation of several hundred genes including those involved in interferon and stress response, immune cells differentiation, neurogenesis, cell cycle etc. and is absolutely necessary for mouse embryogenesis. Brg1 is also involved in cell growth arrest, senescence and tumour supression.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATP-dependent helicase SMARCA4; BAF190A; BRG1-associated factor 190A; FLJ39786; Mitotic growth and transcription activator; Protein brahma homolog 1; Protein BRG-1; SMARCA4; SNF2-beta; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; Transcription activator BRG1
基因别名: b2b508.1Clo; b2b692Clo; BAF190A; brg-1; BRG1; HP1-BP72; SMARCA4; SNF2B; SNF2beta; SNF2L4; SW1/SNF
UniProt ID: (Mouse) Q3TKT4
Entrez Gene ID: (Mouse) 20586, (Rat) 171379
nucleotide binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II transcription coactivator activity
p53 binding
DNA binding
chromatin binding
transcription coactivator activity
transcription corepressor activity
helicase activity
protein binding
ATP binding
DNA-dependent ATPase activity
transcription factor binding
hydrolase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
ATPase activity
Tat protein binding
nucleosomal DNA binding
protein complex binding
histone binding
protein N-terminus binding
androgen receptor binding
DNA polymerase binding
lysine-acetylated histone binding
DNA helicase
negative regulation of transcription from RNA polymerase II promoter
cell morphogenesis
blood vessel development
vasculogenesis
in utero embryonic development
blastocyst growth
blastocyst hatching
liver development
outflow tract morphogenesis
nucleosome assembly
nucleosome disassembly
chromatin remodeling
methylation-dependent chromatin silencing
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
nervous system development
glial cell fate determination
heart development
positive regulation of cell proliferation
DNA methylation on cytosine within a CG sequence
chromatin modification
stem cell population maintenance
neurogenesis
positive regulation of Wnt signaling pathway
extracellular matrix organization
keratinocyte differentiation
negative regulation of cell growth
regulation of cell migration
forebrain development
hindbrain development
embryonic hindlimb morphogenesis
aortic smooth muscle cell differentiation
ATP-dependent chromatin remodeling
negative regulation of apoptotic process
positive regulation of DNA binding
positive regulation by host of viral transcription
histone H3 acetylation
positive regulation of cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic organ morphogenesis
epidermis morphogenesis
positive regulation of sequence-specific DNA binding transcription factor activity
definitive erythrocyte differentiation
heart trabecula formation
negative regulation of androgen receptor signaling pathway
pharyngeal arch artery morphogenesis
lens fiber cell development
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
neural retina development
spermatid development
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