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Invitrogen
Ku70 Monoclonal Antibody (D1-A6)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-42413
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
D1-A6
抗原
Recombinant protein within human ku70 aa 1-150.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
2 mg/mL
规格
200 µg
纯化类型
Protein A
保存液
PBS, pH 7.4, with 40% glycerol, 0.2% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Control: Hela, HepG2, A431, D3, 293T, A549, COS-1, human kidney tissue, human liver tissue, human brain, human thymus tissue, human placentae tissue, mouse kidney tissue, mouse liver tissue, mouse thymus tissue, mouse testis tissue, human tonsil tissue,human breast cancer tissue.
Subcellular Location: Nucleus
靶标信息
XRCC6 is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 5'-dRP/AP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CT; CTA-216E10.7; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein Ku70; DNA repair protein XRCC6; Ku autoantigen protein p70 homolog; Ku p70; Ku70; Lupus Ku autoantigen protein p70; OTTHUMP00000028581; thyroid autoantigen 70 kDa; Thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 6; X-ray repair cross-complementing protein 6
基因别名: 70kDa; G22P1; Ku70; XRCC6
UniProt ID: (Mouse) P23475
Entrez Gene ID: (Mouse) 14375
nucleotide binding
DNA binding
damaged DNA binding
double-stranded DNA binding
double-stranded telomeric DNA binding
catalytic activity
ATP-dependent DNA helicase activity
helicase activity
ATP binding
protein C-terminus binding
hydrolase activity
lyase activity
telomeric DNA binding
transcription regulatory region DNA binding
poly(A) RNA binding
5'-deoxyribose-5-phosphate lyase activity
DNA helicase
telomere maintenance
DNA repair
double-strand break repair
double-strand break repair via nonhomologous end joining
DNA recombination
transcription, DNA-templated
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
metabolic process
response to ionizing radiation
V(D)J recombination
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of neurogenesis
cellular hyperosmotic salinity response
cellular response to X-ray
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