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Invitrogen
ACVR2B Monoclonal Antibody (A5H6)
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ACVR2B Antibody (MA5-42556) in WB
Western blot analysis of ACVR2B on Hela cell lysates. Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. ACVR2B Monoclonal Antibody (Product # MA5-42556) at 1:500 was used in 5% NFDM/TBST at room temperature for 2 hours. Goat Anti-Mouse IgG - HRP Secondary Antibody at 1:20,000 dilution was used for 1 hour at room temperature. Predicted band size: 58 kDa Observed band size: 50 kDa.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-42556
产品规格
种属反应
Human,
Mouse,
Rat,
Zebrafish
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
A5H6
抗原
Synthetic peptide within human ACVR2B aa 331-380.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
2 mg/mL
规格
200 µg
纯化类型
Protein G
保存液
TBS, pH 7.4, with 50% glycerol, 0.2% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Control: Hela cell lysates.
Subcellular Location: Cell membrane.
靶标信息
ACVR2B is a type II member of the TGF-beta family of receptor ser/thr kinases and is involved in the activin and myostatin signaling pathway. Activins and inhibins are members of the TGF-beta superfamily due to amino acid homology with respect to the conservation of 7 of the 9 cysteine residues common to all TGF-beta forms. To date, seven type I and five type II activin receptors have been cloned from mammals, including activin receptor IA, activin receptor IIA, activin receptor IB, and activin receptor IIB. In addition, two splice variants of activin receptor IIA and five splice variants of activin receptor IIB have been reported.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: activin A receptor, type IIB; activin A receptor, type IIBa; activin receptor IIB; Activin receptor type IIB; Activin receptor type-2B; Activine receptor 2b (transmembrane serine kinase); ACTR-IIB; ActRIIB type II activin receptor B; MGC116908; serine/threonine receptor kinase
基因别名: actr2b; ActRIIB; ACVR2B; wu:fj97d11
UniProt ID: (Rat) P38445, (Mouse) P27040
Entrez Gene ID: (Rat) 25366, (Mouse) 11481, (Zebrafish) 30457
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
transforming growth factor beta-activated receptor activity
ATP binding
growth factor binding
inhibin binding
metal ion binding
activin binding
transforming growth factor beta binding
nucleotide binding
protein kinase activity
protein binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
activin-activated receptor activity
serine/threonine protein kinase receptor
skeletal system development
gastrulation with mouth forming second
kidney development
lymphangiogenesis
blood vessel remodeling
regulation of transcription, DNA-templated
protein phosphorylation
signal transduction
determination of left/right symmetry
pattern specification process
mesoderm development
heart development
response to glucose
post-embryonic development
anterior/posterior pattern specification
regulation of signal transduction
sexual reproduction
signal transduction by protein phosphorylation
insulin secretion
lung development
positive regulation of bone mineralization
BMP signaling pathway
pancreas development
activation of protein kinase activity
positive regulation of activin receptor signaling pathway
organ growth
odontogenesis of dentin-containing tooth
positive regulation of osteoblast differentiation
embryonic foregut morphogenesis
skeletal system morphogenesis
palate development
lymphatic endothelial cell differentiation
artery development
venous blood vessel development
retina vasculature development in camera-type eye
transmembrane receptor protein serine/threonine kinase signaling pathway
phosphorylation
neural crest cell migration
hindbrain development
activin receptor signaling pathway
cartilage development
cellular response to growth factor stimulus
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