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Invitrogen

Insulin Recombinant Rabbit Monoclonal Antibody (4C3Y9)

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Insulin Recombinant Rabbit Monoclonal Antibody (4C3Y9)

Product Details

MA5-42679

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:40,000 - 1:160,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

4C3Y9

Immunogen

Synthetic peptide
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.8 mg/mL

Amount

80 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2911820

Product Specific Information

Positive test controls include: Mouse pancreas, Rat pancreas. The target is usually found in the following locations: Secreted.

Immunogen sequence: MALWMRLLPL LALLALWGPD PAAAFVNQHL CGSHLVEALY LVCGERGFFY TPKTRREAED LQVGQVELGG GPGAGSLQPL ALEGSLQKRG IVEQCCTSIC

Target Information

Insulin is a peptide hormone secreted by beta cells of the pancreatic islets. It regulates carbohydrate, protein and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Insulin is 51-amino acid polypeptide product produced from a precursor peptide, proinsulin. Proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds and one molecule of C-peptide. Insulin deficiency results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of b-cell origin such as insulinoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: C-peptide; Ins; Insulin-1; proinsulin; unnamed protein product

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Gene Aliases: CP-II; Ins-1; Ins-2; Ins2-rs1; InsII; Mody; Mody4

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UniProt ID: (Mouse) P01325, (Rat) P01322, (Rat) P01323, (Mouse) P01326

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Entrez Gene ID: (Mouse) 16333, (Rat) 24505, (Rat) 24506, (Mouse) 16334

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Function(s)
protease binding insulin receptor binding insulin-like growth factor receptor binding hormone activity identical protein binding receptor agonist activity zinc ion binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter positive regulation of cytokine production negative regulation of acute inflammatory response glucose metabolic process acute-phase response ER overload response G-protein coupled receptor signaling pathway myoblast fusion biological_process positive regulation of cell proliferation insulin receptor signaling pathway lipid biosynthetic process glycoprotein biosynthetic process regulation of gene expression positive regulation of gene expression negative regulation of gene expression positive regulation of glucose metabolic process myotube differentiation lipid catabolic process lactate biosynthetic process insulin processing positive regulation of cell migration regulation of protein localization protein hexamerization nitric oxide-cGMP-mediated signaling pathway wound healing lipoprotein biosynthetic process negative regulation of protein catabolic process vasodilation regulation of phosphorylation glucose homeostasis positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade negative regulation of gluconeogenesis positive regulation of fatty acid biosynthetic process positive regulation of glycogen biosynthetic process positive regulation of DNA replication negative regulation of glycogen catabolic process positive regulation of glycolytic process positive regulation of mitotic nuclear division negative regulation of fatty acid metabolic process positive regulation of glucose import positive regulation of insulin receptor signaling pathway alpha-beta T cell activation regulation of protein secretion negative regulation of protein secretion positive regulation of protein secretion positive regulation of peptidyl-tyrosine phosphorylation negative regulation of lipid catabolic process positive regulation of lipoprotein lipase activity positive regulation of protein kinase B signaling fatty acid homeostasis relaxation of vascular smooth muscle negative regulation of respiratory burst involved in inflammatory response positive regulation of respiratory burst intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress positive regulation of ERK1 and ERK2 cascade positive regulation of protein localization to nucleus positive regulation of dendritic spine maintenance regulation of protein localization to plasma membrane negative regulation of reactive oxygen species biosynthetic process neuron projection maintenance negative regulation of feeding behavior positive regulation of neuron projection development response to cytokine TORC1 signaling response to peptide hormone positive regulation of translation response to cAMP cellular response to glucose stimulus cellular response to oxygen-containing compound response to dimethyl sulfoxide glucose transmembrane transport negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
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