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Invitrogen

TrkA/TrkB/TrkC Recombinant Rabbit Monoclonal Antibody (8A7M10)

View all (7) TrkA/TrkB/TrkC antibodies

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TrkA/TrkB/TrkC Recombinant Rabbit Monoclonal Antibody (8A7M10)

Product Details

MA5-42792

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

8A7M10

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 722-822 of human NTRK2 (Q16620 )
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.5 mg/mL

Amount

150 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2911933

Product Specific Information

Positive test controls include: SH-SY5Y, Mouse brain, Rat brain.

Immunogen sequence: PESIMYRKFT TESDVWSLGV VLWEIFTYGK QPWYQLSNNE VIECITQGRV LQRPRTCPQE VYELMLGCWQ REPHMRKNIK GIHTLLQNLA KASPVYLDIL G

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: BDNF/NT-3 growth factors receptor; gp140trk; GP145-TrkB; GP145-TrkB/GP95-TrkB; GP145-TrkC; High affinity nerve growth factor receptor; neural receptor protein-tyrosine kinase (trkB); neural receptor protein-tyrosine kinase (trkC); Neurotrophic tyrosine kinase receptor type 1; Neurotrophic tyrosine kinase receptor type 2; Neurotrophic tyrosine kinase receptor type 3; neurotrophic tyrosine receptor kinase type 2; neurotrophin-3; NT-3 growth factor receptor; p140-TrkA; Slow nerve growth factor receptor; trk; Trk-A; Trk-B; Trk-C; TRK1-transforming tyrosine kinase protein; TrkA neurotrophin receptor; trkA proto-oncogene receptor; TrkB tyrosine kinase; TrkC tyrosine kinase; Tropomyosin-related kinase A; Tropomyosin-related kinase B; Tyrosine kinase receptor; Tyrosine kinase receptor A

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Gene Aliases: AW125844; C80751; GP145-TrkB/GP95-TrkB; MTC; NTRK1; NTRK2; NTRK3; Ntrk3_tv3; RATTRKB1; Tkr; Tkrb; TRK; trk-B; TRKA; TRKB; TRKB1; TRKC

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UniProt ID: (Mouse) Q3UFB7, (Rat) P35739, (Mouse) P15209, (Rat) Q63604, (Mouse) Q6VNS1, (Rat) Q03351

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Entrez Gene ID: (Mouse) 18211, (Rat) 59109, (Mouse) 18212, (Rat) 25054, (Mouse) 18213, (Rat) 29613

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Function(s)
nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity neurotrophin receptor activity neurotrophin p75 receptor binding protein binding ATP binding nerve growth factor receptor activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups kinase binding protein homodimerization activity ephrin receptor binding nerve growth factor binding neurotrophin binding brain-derived neurotrophic factor binding brain-derived neurotrophic factor-activated receptor activity p53 binding transmembrane signal receptor
Process(es)
protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development nervous system development axon guidance learning or memory programmed cell death involved in cell development response to activity phosphorylation peptidyl-tyrosine phosphorylation sensory perception of pain cell differentiation B cell differentiation response to nutrient levels response to nicotine nerve growth factor signaling pathway mechanoreceptor differentiation response to drug positive regulation of programmed cell death negative regulation of neuron apoptotic process positive regulation of angiogenesis protein autophosphorylation neurotrophin TRK receptor signaling pathway sympathetic nervous system development detection of temperature stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception of pain positive regulation of NF-kappaB transcription factor activity response to electrical stimulus positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic Sertoli cell development innervation axonogenesis involved in innervation behavioral response to formalin induced pain cellular response to nicotine cellular response to growth factor stimulus negative regulation of neuron death cellular response to nerve growth factor stimulus aging circadian rhythm negative regulation of cell proliferation response to radiation positive regulation of neuron projection development olfactory nerve development response to ethanol positive regulation of Ras protein signal transduction response to axon injury response to hydrostatic pressure positive regulation of ERK1 and ERK2 cascade vasculogenesis neuron migration neuromuscular junction development learning long-term memory feeding behavior positive regulation of cell proliferation positive regulation of gene expression glutamate secretion positive regulation of phosphatidylinositol 3-kinase signaling regulation of metabolic process central nervous system neuron development cerebral cortex development neuron differentiation brain-derived neurotrophic factor receptor signaling pathway positive regulation of peptidyl-serine phosphorylation calcium-mediated signaling using intracellular calcium source neurotrophin signaling pathway regulation of GTPase activity regulation of MAPK cascade positive regulation of MAPK cascade retinal rod cell development regulation of neurotransmitter secretion oligodendrocyte differentiation peripheral nervous system neuron development positive regulation of axonogenesis regulation of dendrite development regulation of protein kinase B signaling retina development in camera-type eye long-term synaptic potentiation cellular response to amino acid stimulus positive regulation of glucocorticoid receptor signaling pathway negative regulation of anoikis inflammatory response response to light stimulus response to auditory stimulus cellular response to tumor necrosis factor cellular response to brain-derived neurotrophic factor stimulus activation of MAPK activity negative regulation of protein phosphorylation positive regulation of cell migration activation of protein kinase B activity positive regulation of apoptotic process neuron fate specification positive regulation of axon extension involved in regeneration negative regulation of astrocyte differentiation positive regulation of positive chemotaxis negative regulation of cell death lens fiber cell differentiation activation of GTPase activity positive regulation of actin cytoskeleton reorganization modulation by virus of host transcription response to corticosterone cellular response to retinoic acid cochlea development
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