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Invitrogen

HDAC1 Monoclonal Antibody (E22)

View all (36) HDAC1 antibodies

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HDAC1 Monoclonal Antibody (E22)

Product Details

MA5-43779

Applications
Tested Dilution
Publications

Western Blot (WB)

0.01-2 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

5-20 µg/mL
-

Immunocytochemistry (ICC/IF)

5-20 µg/mL
-

Flow Cytometry (Flow)

10 µg/mL
-
Product Specifications

Species Reactivity

Bovine, Human, Mouse, Rat

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

E22

Immunogen

Met1-Ala482 (Accession Q13547), with N-terminal His Tag
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A/G

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2912711

Target Information

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. HDAC1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, HDAC1 deacetylates p53 and modulates its effect on cell growth and apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DKFZp686H12203; HD1; HDAC1; protein deacetylase HDAC1; protein deacylase HDAC1; protein decrotonylase HDAC1; reduced potassium dependency, yeast homolog-like 1; RP4-811H24.2; unnamed protein product

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Gene Aliases: GON-10; HD1; Hdac1-ps; KDAC1; MommeD5; RPD3; RPD3L1

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UniProt ID: (Bovine) Q32PJ8, (Human) Q13547, (Mouse) O09106, (Rat) Q4QQW4

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Entrez Gene ID: (Bovine) 404126, (Human) 3065, (Mouse) 433759, (Rat) 297893

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Function(s)
histone deacetylase activity deacetylase activity NAD-dependent histone deacetylase activity (H3-K14 specific) transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding core promoter sequence-specific DNA binding transcription corepressor binding p53 binding DNA binding chromatin binding transcription corepressor activity protein binding hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides enzyme binding nucleosomal DNA binding protein deacetylase activity Krueppel-associated box domain binding histone deacetylase binding NF-kappaB binding RNA polymerase II sequence-specific DNA binding transcription factor binding E-box binding DNA-binding transcription factor binding histone deacetylase activity, hydrolytic mechanism protein decrotonylase activity histone decrotonylase activity protein lysine delactylase activity promoter-specific chromatin binding macromolecular complex binding
Process(es)
circadian regulation of gene expression negative regulation of transcription, DNA-templated histone H4 deacetylation negative regulation of transcription from RNA polymerase II promoter response to amphetamine chromatin organization chromatin remodeling methylation-dependent chromatin silencing regulation of transcription from RNA polymerase II promoter endoderm development circadian rhythm positive regulation of cell proliferation negative regulation of cell proliferation response to xenobiotic stimulus epidermal cell differentiation positive regulation of gene expression negative regulation of gene expression hippocampus development negative regulation of Wnt signaling pathway neuron differentiation negative regulation of cell migration negative regulation of transforming growth factor beta receptor signaling pathway response to caffeine heterochromatin assembly response to lipopolysaccharide positive regulation of interleukin-1 production positive regulation of tumor necrosis factor production positive regulation of intracellular estrogen receptor signaling pathway cellular response to oxidative stress cellular response to platelet-derived growth factor stimulus odontogenesis of dentin-containing tooth regulation of cell fate specification embryonic digit morphogenesis negative regulation of apoptotic process negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of neuron apoptotic process negative regulation by host of viral transcription negative regulation of gene expression, epigenetic positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of insulin secretion positive regulation of smooth muscle cell proliferation positive regulation of oligodendrocyte differentiation response to hyperoxia negative regulation of androgen receptor signaling pathway hair follicle placode formation eyelid development in camera-type eye fungiform papilla formation cellular response to tumor necrosis factor negative regulation of canonical Wnt signaling pathway negative regulation of stem cell population maintenance positive regulation of stem cell population maintenance positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of type B pancreatic cell apoptotic process regulation of stem cell differentiation negative regulation of intrinsic apoptotic signaling pathway negative regulation of myotube differentiation regulation of embryonic development negative regulation of cell communication negative regulation of signaling positive regulation of protein modification process negative regulation of peptidyl-lysine acetylation
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