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Invitrogen

CXCL12 Monoclonal Antibody (C3)

View all (25) CXCL12 antibodies

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CXCL12 Monoclonal Antibody (C3)

Product Details

MA5-43866

Applications
Tested Dilution
Publications

Western Blot (WB)

0.01-2 µg/mL
-

Immunocytochemistry (ICC/IF)

20 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

C3

Immunogen

Pro23-Lys89 (Accession P48061), with N-terminal His and GST Tag
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

20 µg

Purification

Protein A/G

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2912798

Target Information

CXCL12 is a stromal cell-derived alpha chemokine member of the intercrine family. This gene product and its receptor CXCR4 can activate lymphocytes and have been implicated in the metastasis of some cancers such as breast cancer. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AI174028; C Cmotif chemokine; C X C motif chemokine; C-X-C motif chemokine 12; CC motif chemokine; CCmotif chemokine; chemokine; chemokine (C-X-C motif) ligand 12; CXC; CXC motif chemokine; CXCL; CXCL12; hIRH; hSDF-1; Intercrine reduced in hepatomas; IRH; PBSF; Pre-B cell growth-stimulating factor; SDF-1; SDF-1 delta; chemokine (C-X-C motif) ligand 12 transcript variant 5; SDF-1 epsilon; chemokine (C-X-C motif) ligand 12 transcript variant 6; SDF-1 gamma; chemokine (C-X-C motif) ligand 12 transcript variant 4; SDF-1 theta; chemokine (C-X-C motif) ligand 12 transcript variant 7; SDF-1a; SDF-1b; SDF1a; Stromal cell-derived factor 1; stromal cell-derived factor-1 alpha; TLSF-a; TLSF-b; Tlsfa; Tlsfb; unnamed protein product

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Gene Aliases: CXCL12; IRH; PBSF; SCYB12; SDF1; SDF1A; SDF1B; TLSF; TPAR1

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UniProt ID: (Human) P48061

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Entrez Gene ID: (Human) 6387

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Function(s)
receptor binding cytokine activity integrin binding protein binding chemokine activity growth factor activity chemokine receptor binding CXCR chemokine receptor binding
Process(es)
response to hypoxia neuron migration positive regulation of endothelial cell proliferation cellular calcium ion homeostasis chemotaxis defense response immune response cell adhesion signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway axon guidance blood circulation regulation of actin polymerization or depolymerization positive regulation of cell proliferation adult locomotory behavior response to mechanical stimulus response to virus T cell chemotaxis telencephalon cell migration positive regulation of cell migration organ regeneration killing of cells of other organism positive regulation of dopamine secretion integrin activation chemokine (C-X-C motif) ligand 12 signaling pathway CXCL12-activated CXCR4 signaling pathway response to peptide hormone positive regulation of neuron differentiation positive regulation of cell adhesion positive regulation of axon extension involved in axon guidance positive regulation of chemotaxis induction of positive chemotaxis detection of temperature stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception of pain regulation of calcium ion transport cell chemotaxis antimicrobial humoral immune response mediated by antimicrobial peptide chemokine-mediated signaling pathway positive regulation of monocyte chemotaxis positive regulation of calcium ion import negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of leukocyte tethering or rolling positive regulation of vasculature development response to ultrasound cellular response to chemokine positive regulation of T cell migration negative regulation of dendritic cell apoptotic process
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