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Invitrogen

RXRA Monoclonal Antibody (5E7)

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RXRA Monoclonal Antibody (5E7)

产品信息

MA5-49193

应用
建议稀释比
已发表文章

免疫印迹 (WB)

0.1-0.5 µg/mL
-

流式细胞分析 (Flow)

1-3 µg/1x10^6 cells
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

5E7

抗原

E. coli-derived human RXRA recombinant protein (Position: A226-T462).
3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

500 µg/mL

规格

100 µg

纯化类型

Antigen affinity chromatography

保存液

PBS with 4mg trehalose

内含物

0.05mg sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_3074851

产品详细信息

Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.

Positive Control - WB: human Hela whole cell, human A549 whole cell, human HepG2 whole cell, human Caco-2 whole cell, human HL-60 whole cell, rat liver tissue, mouse liver tissue. Flow: A549 cell, CACO-2 cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

靶标信息

Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells. The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer. RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Nuclear receptor subfamily 2 group B member 1; Retinoic acid receptor RXR-alpha; retinoid X receptor; Retinoid X receptor alpha; rxr alpha; RXR alpha 1

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基因别名: 9530071D11Rik; NR2B1; RXRA; RXRalpha1

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UniProt ID: (Mouse) P28700

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Entrez Gene ID: (Rat) 25271, (Mouse) 20181

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功能
RNA polymerase II regulatory region sequence-specific DNA binding DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding 9-cis retinoic acid receptor activity protein binding transcription factor binding zinc ion binding enzyme binding protein domain specific binding chromatin DNA binding protein complex binding vitamin D receptor binding retinoic acid receptor binding sequence-specific DNA binding transcription regulatory region DNA binding retinoic acid-responsive element binding protein heterodimerization activity vitamin D response element binding metal ion binding C4 zinc finger nuclear receptor
参与通路
negative regulation of transcription from RNA polymerase II promoter in utero embryonic development liver development placenta development maternal placenta development transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter inflammatory response midgut development heart development female pregnancy embryo implantation aging response to nutrient negative regulation of cell proliferation response to selenium ion response to organic cyclic compound modulation by virus of host morphology or physiology axon regeneration regulation of myelination response to retinoic acid cellular response to insulin stimulus response to vitamin A response to vitamin D peroxisome proliferator activated receptor signaling pathway camera-type eye development positive regulation of apoptotic process steroid hormone mediated signaling pathway response to ethanol positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of translational initiation by iron retinoic acid receptor signaling pathway protein homotetramerization response to glucocorticoid ventricular cardiac muscle tissue morphogenesis ventricular cardiac muscle cell differentiation cardiac muscle cell proliferation secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development regulation of branching involved in prostate gland morphogenesis positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus heart morphogenesis negative regulation of gene expression cardiac muscle cell differentiation mesenchyme development angiogenesis involved in coronary vascular morphogenesis visceral serous pericardium development
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