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Invitrogen
SOX10 Recombinant Rabbit Monoclonal Antibody (PDH0-03)
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图: 1 / 10
SOX10 Antibody (MA5-50754) in ICC/IF
Immunocytochemistry analysis of SOX10 in A375 cells. Cells were fixed in 4% paraformaldehyde for 10 minutes at 37 &(8)451;, permeabilized with 0.05% Triton X-100 in PBS for 20 minutes, and then blocked with 2% negative goat serum for 30 minutes at room temperature. Cells were incubated with SOX10 recombinant monoclonal antibody (Product # MA5-50754) with a dilution of 1:50 in 2% negative goat serum overnight at 4 &(8)451;. Followed by secondary antibody Goat Anti-Rabbit IgG H&L (iFluor™ 488) at a dilution of 1:1,000. PBS instead of the pri... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-50754
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
PDH0-03
抗原
Synthetic peptide within C terminal human SOX10.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.01 mg/mL
规格
101 µg
纯化类型
Protein A
保存液
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive control: A375 cell lysate, B16F1 cell lysate, human malignant melanoma tissue, human breast tissue, rat cerebellum tissue, mouse brain tissue, A375, B16F1.
Predicted band size: 50 kDa
Subcellular Location: Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleus.
靶标信息
SOX10 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. This protein may act as a transcriptional activator after forming a protein complex with other proteins. It acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: dominant megacolon; MGC15649; Protein SOX-21; SRY; SRY-box containing gene 10; Transcription factor SOX-10; Transcription factor SOX-M
基因别名: Dom; Sox-10; SOX10; Sox21
UniProt ID: (Rat) O55170, (Mouse) Q04888
Entrez Gene ID: (Rat) 29361, (Mouse) 20665
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription factor binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
transcription factor binding
identical protein binding
transcription regulatory region DNA binding
in utero embryonic development
neural crest cell migration
positive regulation of neuroblast proliferation
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
peripheral nervous system development
positive regulation of gliogenesis
cell differentiation
melanocyte differentiation
lacrimal gland development
negative regulation of apoptotic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cell development
cell maturation
enteric nervous system development
digestive tract morphogenesis
developmental growth
oligodendrocyte differentiation
stem cell differentiation
morphogenesis of a branching epithelium
negative regulation of canonical Wnt signaling pathway
transcription, DNA-templated
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