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Invitrogen
RNF8 Recombinant Rabbit Monoclonal Antibody (8M7D8)
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RNF8 Antibody (MA5-51454) in IHC (P)
Immunohistochemistry analysis of RNF8 in paraffin-embedded human testis. Samples were incubated with RNF8 Recombinant monoclonal antibody (Product # MA5-51454) using a dilution of 1:300 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-51454
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
8M7D8
抗原
Recombinant protein (or fragment)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.215 mg/mL
规格
21.5 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MGEPGFFVTG DRAGGRSWCL RRVGMSAGWL LLEDGCEVTV GRGFGVTYQL VSKICPLMIS RNHCVLKQNP EGQWTIMDNK SLNGVWLNRA RLEPLRVYSI HQGDYIQLGV PLENKENAEY EYEVTEEDWE TIYPCLSPKN DQMIEKNKEL RTKRKFSLDE LAGPGAEGPS NLKSKINKVS CESGQPVKSQ GKGEVASTPS DNLDPKLTAL EPSKTTGAPI YPGFPKVTEV HHEQKASNSS ASQRSLQMFK VTMSRILRLK
靶标信息
The protein encoded by this gene contains a RING finger motif and a FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ActA binding protein 2; ActA-interacting protein 37; AIP37; E3 ubiquitin-protein ligase RNF8; FLJ12013; hRNF8; LaXp180; OTTHUMP00000039684; RING finger protein 8; RING-type E3 ubiquitin transferase RNF8
基因别名: 3830404E21Rik; AIP37; KIAA0646; RNF8
UniProt ID: (Rat) Q4KLN8, (Mouse) Q8VC56
Entrez Gene ID: (Rat) 361815, (Mouse) 58230
molecular_function
chromatin binding
ubiquitin-protein transferase activity
zinc ion binding
acid-amino acid ligase activity
ubiquitin protein ligase binding
histone binding
protein homodimerization activity
ubiquitin protein ligase activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
ubiquitin-protein ligase
protein modifying enzyme
double-strand break repair
double-strand break repair via nonhomologous end joining
ubiquitin-dependent protein catabolic process
cellular response to DNA damage stimulus
mitotic nuclear division
spermatid development
biological_process
response to ionizing radiation
histone H2A ubiquitination
histone H2B ubiquitination
negative regulation of transcription elongation from RNA polymerase II promoter
histone exchange
isotype switching
positive regulation of DNA repair
cell division
protein autoubiquitination
protein K63-linked ubiquitination
histone H2A K63-linked ubiquitination
protein K48-linked ubiquitination
DNA repair
cell cycle
protein ubiquitination
chromatin modification
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