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Invitrogen
CaMKII Pan Recombinant Rabbit Monoclonal Antibody (23GB5920)
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图: 1 / 3
CaMKII Pan Antibody (MA5-52950) in ICC/IF
Immunocytochemistry analysis of CaMKII Pan in HepG2 cells. Sample was incubated with CaMKII Pan monoclonal (Product # MA5-52950) antibody at a dilution of 1:1,000, followed by DAPI and Alexa Fluor 647. Protein abundance based on laser intensity and smart gain: Low. Scale bar: 20 μm.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-52950
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
23GB5920
抗原
A synthesized peptide derived from human CaMKII (1-88AA).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is an ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+/calmodulin (CaM) binding and autophosphorylation and has been implicated in regulation of the cell cycle and transcription. It is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: alpha-CaMKII; Ca2+/calmodulin-dependent protein kinase II; Calcium/calmodulin-dependent protein kinase type II subunit alpha; Calcium/calmodulin-dependent protein kinase type II subunit beta; Calcium/calmodulin-dependent protein kinase type II subunit delta; Calcium/calmodulin-dependent protein kinase type II subunit gamma; CaM kinase II subunit alpha; CaM kinase II subunit beta; CaM kinase II subunit delta; CaM kinase II subunit gamma; CaMK II; caMK-II subunit alpha; caMK-II subunit beta; caMK-II subunit delta; caMK-II subunit gamma
基因别名: 2810011D23Rik; 8030469K03Rik; [d]-CaMKII; CAM2; CAMK; CaMK II; CAMK-II; CAMK2; CAMK2A; CAMK2B; CAMK2D; CAMK2G; CAMKA; CAMKB; CAMKD; CAMKG; CaMKII; KIAA0968; Kiaa4163; mKIAA0968; R74975
UniProt ID: (Mouse) P11798, (Mouse) P28652, (Mouse) Q6PHZ2, (Mouse) Q923T9
Entrez Gene ID: (Mouse) 12322, (Mouse) 12323, (Mouse) 108058, (Mouse) 12325
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
calmodulin-dependent protein kinase activity
protein binding
calmodulin binding
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
GTPase activating protein binding
glutamate receptor binding
protein homodimerization activity
phospholipase binding
sodium channel inhibitor activity
titin binding
ion channel binding
nitric-oxide synthase binding
non-receptor serine/threonine protein kinase
G1/S transition of mitotic cell cycle
response to ischemia
protein phosphorylation
calcium ion transport
positive regulation of cardiac muscle cell apoptotic process
phosphorylation
peptidyl-serine phosphorylation
ionotropic glutamate receptor signaling pathway
angiotensin-activated signaling pathway
protein autophosphorylation
regulation of neurotransmitter secretion
regulation of neuronal synaptic plasticity
positive regulation of NF-kappaB transcription factor activity
positive regulation of calcium ion transport
regulation of mitochondrial membrane permeability involved in apoptotic process
inhibitory G-protein coupled receptor phosphorylation
nervous system development
positive regulation of neuron projection development
cell differentiation
regulation of synaptic transmission, cholinergic
positive regulation of phospholipase A2 activity
response to cadmium ion
regulation of long-term neuronal synaptic plasticity
cell projection morphogenesis
neuromuscular process controlling balance
long-term synaptic potentiation
activation of meiosis involved in egg activation
positive regulation of dendritic spine morphogenesis
positive regulation of synapse maturation
positive regulation of apoptotic signaling pathway
response to hypoxia
regulation of sodium ion transport
regulation of membrane depolarization
regulation of G2/M transition of mitotic cell cycle
positive regulation of cardiac muscle hypertrophy
regulation of cell communication by electrical coupling
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
positive regulation of smooth muscle cell migration
peptidyl-threonine phosphorylation
cellular potassium ion homeostasis
endoplasmic reticulum calcium ion homeostasis
positive regulation of Rac protein signal transduction
positive regulation of smooth muscle cell proliferation
protein oligomerization
relaxation of cardiac muscle
cardiac muscle contraction
regulation of cellular localization
cell growth involved in cardiac muscle cell development
positive regulation of ERK1 and ERK2 cascade
cardiac muscle cell contraction
regulation of cardiac muscle cell action potential
regulation of relaxation of cardiac muscle
negative regulation of sodium ion transmembrane transport
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
negative regulation of sodium ion transmembrane transporter activity
response to oxidative stress
multicellular organism development
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