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Invitrogen
HES5 Recombinant Rabbit Monoclonal Antibody (23GB6360)
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图: 1 / 2
HES5 Antibody (MA5-53026) in ICC/IF
Immunocytochemistry analysis of HES5 in HepG2 cells. Sample was incubated with HES5 monoclonal (Product # MA5-53026) antibody at a dilution of 1:1,000, followed by DAPI and Alexa Fluor 647. Protein abundance based on laser intensity and smart gain: Medium. Scale bar: 20 μm.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-53026
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
23GB6360
抗原
A synthesized peptide derived from human HES5 (1-166AA).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Hairy and Enhancer-of-split homologues 5 (HES5) is a helix-loop-helix transcriptional factor that negatively regulates cell differentiation during embryogenesis. It contains one basic helix-loop-helix (bHLH) domain and one Orange domain. HES5 is reported to be a down stream effector of the Notch Signaling Pathway and is expressed in advanced ovarian serous adenocarcinomas as well as in cervical squamous carcinoma. Reports also suggest that HES5 is abundantly expressed in osteoarthritis along with Notch1 and Jagged1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bHLHb38; Class B basic helix-loop-helix protein 38; Hairy and enhancer of split 5; Notch pathway transcription factor; RP3-395M20.5; Transcription factor HES-5; unnamed protein product
基因别名: BHLHB38; HES5
Entrez Gene ID: (Human) 388585, (Mouse) 15208, (Rat) 79225
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
protein dimerization activity
sequence-specific double-stranded DNA binding
chromatin binding
double-stranded DNA binding
protein binding
negative regulation of transcription from RNA polymerase II promoter
chondrocyte differentiation
regulation of transcription, DNA-templated
cell adhesion
Notch signaling pathway
smoothened signaling pathway
brain development
positive regulation of cell proliferation
anterior/posterior pattern specification
oligodendrocyte development
telencephalon development
glial cell fate commitment
forebrain radial glial cell differentiation
neural tube development
central nervous system myelination
neuron differentiation
positive regulation of BMP signaling pathway
regulation of myelination
camera-type eye development
regulation of cell differentiation
negative regulation of auditory receptor cell differentiation
negative regulation of neuron differentiation
positive regulation of Notch signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JAK-STAT cascade
cell maturation
animal organ development
positive regulation of smooth muscle cell proliferation
astrocyte differentiation
negative regulation of astrocyte differentiation
negative regulation of oligodendrocyte differentiation
system development
regulation of epithelial cell proliferation
regulation of neurogenesis
cartilage development
inner ear receptor stereocilium organization
protein-containing complex assembly
comma-shaped body morphogenesis
S-shaped body morphogenesis
specification of loop of Henle identity
metanephric nephron tubule morphogenesis
establishment of epithelial cell polarity
neuronal stem cell population maintenance
negative regulation of stem cell differentiation
negative regulation of pro-B cell differentiation
negative regulation of forebrain neuron differentiation
negative regulation of inner ear receptor cell differentiation
negative regulation of cell differentiation
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