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Invitrogen
GTPBP4 Recombinant Rabbit Monoclonal Antibody (23GB6455)
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FIGURE: 1 / 3
GTPBP4 Antibody (MA5-53054) in ICC/IF
Immunocytochemistry analysis of GTPBP4 in HepG2 cells. Sample was incubated with GTPBP4 monoclonal (Product # MA5-53054) antibody at a dilution of 1:1,000, followed by DAPI and Alexa Fluor 647. Protein abundance based on laser intensity and smart gain: Medium. Scale bar: 20 μm.
Product Details
MA5-53054
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
23GB6455
Immunogen
A synthesized peptide derived from human GTPBP4 (50-100AA).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Chronic renal failure gene protein; chronic renal failure protein; FLJ10686; FLJ10690; FLJ39774; G protein-binding protein CRFG; GTP binding protein 3; GTP-binding protein 4; GTP-binding protein NGB; Nucleolar GTP-binding protein 1; Nucleolar GTP-binding protein 1 (Chronic renal failure gene protein) (GTP-binding protein NGB); unnamed protein product
Gene Aliases: 2610028C09Rik; CRFG; Gtpbp3; GTPBP4; NGB; NOG1
UniProt ID: (Human) Q9BZE4, (Mouse) Q99ME9
Entrez Gene ID: (Human) 23560, (Mouse) 69237, (Rat) 114300
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
osteoblast differentiation
negative regulation of DNA replication
negative regulation of cell proliferation
negative regulation of G2/M transition of mitotic cell cycle
negative regulation of cell-cell adhesion
negative regulation of cell migration
negative regulation of protein ubiquitination
ribosome biogenesis
ribosomal large subunit biogenesis
protein stabilization
regulation of cyclin-dependent protein serine/threonine kinase activity
metabolic process
negative regulation of collagen binding
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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