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Invitrogen
FKBP4 Recombinant Rabbit Monoclonal Antibody (23GB1915)
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图: 1 / 3
FKBP4 Antibody (MA5-53111) in ICC/IF
Immunocytochemistry analysis of FKBP4 in HepG2 cells. Nuclei were stained blue with DAPI; FKBP4 recombinant monoclonal antibody (Product # MA5-53110) with a dilution of 1:1,000 was stained magenta with Alexa Fluor 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: High. Scale bar: 20 μm.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-53111
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
23GB1915
抗原
A synthesized peptide derived from human FKBP52 (1-56AA).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.38 mg/mL
规格
7.6 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
FKBP4, encoding FK506-binding protein 4, is part of the immunophilin family and plays roles in cellular processes like protein folding and trafficking. The FKBP4 gene is located on chromosome 12, where it encodes a protein involved in modulating the androgen receptor signaling pathway and has been implicated in various cancers, including non-small-cell lung cancer (NSCLC) and hepatocellular carcinoma (HCC). Structural variants of FKBP4 found through exome sequencing have shown potential deleterious effects on protein function. This gene is associated with cell proliferation, apoptosis, migration, and invasion in cancer cells. FKBP4 also influences metabolic processes, such as glycolysis, thereby contributing to cancer cell survival and growth. Importantly, FKBP4 has a role in disorders of sexual development due to its regulatory interaction with hormone signaling pathways.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 51 kDa FK506-binding protein; 52 kDa FK506-binding protein; 52 kDa FKBP; 59 kDa immunophilin; FK506 binding protein 52; FK506-binding protein 4; FKBP-4; FKBP51; FKBP52 protein; FKBP59; HBI; HSP-binding immunophilin; Immunophilin FKBP52; p59; Peptidyl-prolyl cis-trans isomerase FKBP4; PPIase FKBP4; Rotamase
基因别名: 59kDa; AL022792; AW208983; FKBP-4; FKBP-52; FKBP4; FKBP52; FKPB52; p59
UniProt ID: (Mouse) P30416, (Rat) Q9QVC8
Entrez Gene ID: (Mouse) 14228, (Rat) 260321
protein peptidyl-prolyl isomerization
protein folding
steroid hormone receptor complex assembly
copper ion transport
embryo implantation
androgen receptor signaling pathway
prostate gland development
negative regulation of microtubule polymerization
protein complex localization
male sex differentiation
reproductive structure development
chaperone-mediated protein folding
negative regulation of neuron projection development
negative regulation of microtubule polymerization or depolymerization
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
