Search
Invitrogen
Phospho-EGFR (Tyr1173) Recombinant Rabbit Monoclonal Antibody (23GB3900)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
图: 1 / 3
Phospho-EGFR (Tyr1173) Antibody (MA5-53661) in WB
Western Blot analysis of EGFR. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with EGFR recombinant monoclonal antibody (Product # MA5-53660) with a dilution of 1:5,000, followed by HRP-conjugated goat anti-rabbit secondary antibody with a dilution of 1:20,000. Image was developed using FeQTM ECL Substrate Kit.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-53661
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
23GB3900
抗原
A synthetic peptide of human EGFR Full-length sequence 1210aa around the phosphorylation site of Tyrosine 1197 (1166-1180AA).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
EGFR, epidermal growth factor receptor, is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. EGFR is encoded by the EGFR gene located on chromosome 7 in humans. EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain. Overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: 2.7.10.1; avian erythroblastic leukemia viral (v-erbB) oncogene homolog; EC 2.7.10.1; EGFR-related peptide; Epidermal growth factor receptor; Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); kinase EGFR; Oncogene ERBB; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1; Urogastrone
基因别名: EGFR; ERBB; ErbB-1; ERBB1; Errp; HER1
Entrez Gene ID: (Rat) 24329
glycoprotein binding
chromatin binding
protein tyrosine kinase activity
receptor signaling protein tyrosine kinase activity
signal transducer activity
transmembrane signaling receptor activity
epidermal growth factor-activated receptor activity
receptor binding
integrin binding
protein binding
ATP binding
kinase activity
enzyme binding
protein kinase binding
protein phosphatase binding
nitric-oxide synthase regulator activity
ubiquitin protein ligase binding
identical protein binding
protein heterodimerization activity
epidermal growth factor binding
actin filament binding
transmembrane signal receptor
activation of MAPKK activity
cell morphogenesis
liver development
embryonic placenta development
positive regulation of protein phosphorylation
hair follicle development
translation
response to osmotic stress
response to oxidative stress
signal transduction
cell surface receptor signaling pathway
epidermal growth factor receptor signaling pathway
salivary gland morphogenesis
learning or memory
circadian rhythm
cell proliferation
positive regulation of cell proliferation
epidermis development
magnesium ion homeostasis
response to organic cyclic compound
diterpenoid metabolic process
single organismal cell-cell adhesion
peptidyl-tyrosine phosphorylation
cerebral cortex cell migration
signal transduction by protein phosphorylation
lung development
positive regulation of cell migration
positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
response to estradiol
positive regulation of superoxide anion generation
response to cobalamin
response to hydroxyisoflavone
response to lipid
positive regulation of catenin import into nucleus
intracellular signal transduction
cellular response to drug
regulation of cell proliferation
negative regulation of protein catabolic process
positive regulation of phosphorylation
ovulation cycle
hydrogen peroxide metabolic process
negative regulation of apoptotic process
positive regulation of MAP kinase activity
tongue development
positive regulation of nitric oxide biosynthetic process
positive regulation of DNA repair
positive regulation of DNA replication
positive regulation of vasoconstriction
positive regulation of vasodilation
negative regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
protein autophosphorylation
astrocyte activation
positive regulation of fibroblast proliferation
digestive tract morphogenesis
positive regulation of smooth muscle cell proliferation
neuron projection morphogenesis
positive regulation of epithelial cell proliferation
positive regulation of inflammatory response
regulation of peptidyl-tyrosine phosphorylation
regulation of nitric-oxide synthase activity
response to calcium ion
positive regulation of protein kinase B signaling
positive regulation of synaptic transmission, glutamatergic
morphogenesis of an epithelial fold
response to UV-A
positive regulation of ERK1 and ERK2 cascade
cellular response to amino acid stimulus
cellular response to mechanical stimulus
cellular response to growth factor stimulus
cellular response to epidermal growth factor stimulus
cellular response to estradiol stimulus
cellular response to dexamethasone stimulus
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
