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Invitrogen
Cathepsin H/K/L/V Recombinant Rabbit Monoclonal Antibody (23GB5780)
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FIGURE: 1 / 2
Cathepsin H/K/L/V Antibody (MA5-53922) in WB
Western Blot analysis of Cathepsin H/K/L/V. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with Cathepsin H/K/L/V recombinant monoclonal antibody (Product # MA5-53922) with a dilution of 1:5,000, followed by HRP-conjugated goat anti-rabbit secondary antibody with a dilution of 1:20,000. Image was developed using FeQTM ECL Substrate Kit.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-53922
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
23GB5780
Immunogen
A synthesized peptide derived from human Cathepsin L/V/K/H (110-135AA).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cat H; Cat K; Cat L; Cathepsin B3; Cathepsin BA; Cathepsin K; Cathepsin L1; Cathepsin L2; Cathepsin O; Cathepsin O2; Cathepsin U; Cathepsin V; Cathepsin X; furless; Major excreted protein; MEP; minisatellite 10q detected by probe MMS10; nackt; p39 cysteine proteinase; Pro-cathepsin H; Procathepsin L
Gene Aliases: 1190035F06Rik; AI323530; AL022844; catK; CATL2; CPSB; CTSH; CTSK; CTSL; CTSL1; CTSL2; CTSO; CTSO2; CTSU; CTSV; fs; MEP; MMS10-Q; Ms10q; nkt; UNQ268/PRO305
UniProt ID: (Mouse) P49935, (Mouse) P55097, (Mouse) P06797
Entrez Gene ID: (Mouse) 13036, (Mouse) 13038, (Mouse) 13039
endopeptidase activity
aminopeptidase activity
cysteine-type endopeptidase activity
serine-type endopeptidase activity
peptidase activity
cysteine-type peptidase activity
cysteine-type endopeptidase activator activity involved in apoptotic process
peptidase activator activity involved in apoptotic process
hydrolase activity
HLA-A specific activating MHC class I receptor activity
kininogen binding
protein complex binding
protein self-association
thyroid hormone binding
fibronectin binding
collagen binding
proteoglycan binding
protein binding
cysteine-type carboxypeptidase activity
peptide binding
histone binding
cysteine protease
T cell mediated cytotoxicity
immune response-regulating signaling pathway
proteolysis
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of cell proliferation
positive regulation of gene expression
positive regulation of epithelial cell migration
neuropeptide catabolic process
bradykinin catabolic process
positive regulation of peptidase activity
positive regulation of cell migration
zymogen activation
protein destabilization
response to retinoic acid
membrane protein proteolysis
negative regulation of apoptotic process
surfactant homeostasis
positive regulation of angiogenesis
proteolysis involved in cellular protein catabolic process
dichotomous subdivision of terminal units involved in lung branching
ERK1 and ERK2 cascade
positive regulation of apoptotic signaling pathway
collagen catabolic process
bone resorption
regulation of mitophagy
positive regulation of protein targeting to mitochondrion
cell communication
negative regulation of keratinocyte proliferation
protein processing
protein autoprocessing
hair follicle morphogenesis
catagen
decidualization
epithelial tube branching involved in lung morphogenesis
regulation of actin cytoskeleton reorganization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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