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Invitrogen
AGTR1 VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA1005)
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Product Details
MA5-54369
Product Specifications
Species Reactivity
Human
Host/Isotype
Alpaca
/ VHH
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
SAA1005
Immunogen
Recombinant Human AGTR1.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.56 mg/mL
Amount
100 µg
Purification
Metal-chelate chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
Product Specific Information
Compatible with Direct ELISA
Target Information
AGTR1 is known as Angiotensin II Type 1 Receptor. Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. And it acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. Moreover, this gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Angiotensin II type-1 receptor; Angiotensin II type-1 receptor A; angiotensin II type-1A receptor; angiotensin receptor 1; angiotensin receptor 1a; AT1 receptor; AT1 receptor A; AT1AR; AT1BR; Type-1 angiotensin II receptor; Type-1 angiotensin II receptor A; type-1A angiotensin II receptor; type-1B angiotensin II receptor; unnamed protein product
Gene Aliases: 1810074K20Rik; AG2S; Agtr-1a; AGTR1; AGTR1A; AGTR1B; AI551199; Angtr-1a; AT1; AT1a; AT1AR; AT1B; AT1BR; AT1R; AT2R1; AT2R1A; AT2R1B; ATR1; HAT1R
UniProt ID: (Human) P30556, (Mouse) P29754
Entrez Gene ID: (Human) 185, (Mouse) 11607
angiotensin type I receptor activity
G-protein coupled receptor activity
angiotensin type II receptor activity
protein binding
bradykinin receptor binding
protein heterodimerization activity
G-protein alpha-subunit binding
signal transducer activity
peptide hormone binding
protein kinase binding
D1 dopamine receptor binding
protein self-association
G-protein coupled receptor
regulation of cell growth
kidney development
renin-angiotensin regulation of aldosterone production
regulation of blood vessel size by renin-angiotensin
regulation of systemic arterial blood pressure by renin-angiotensin
inflammatory response
signal transduction
G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
Rho protein signal transduction
positive regulation of macrophage derived foam cell differentiation
regulation of vasoconstriction
calcium-mediated signaling
low-density lipoprotein particle remodeling
regulation of renal sodium excretion
angiotensin-activated signaling pathway
regulation of cell proliferation
viral entry into host cell
regulation of inflammatory response
positive regulation of inflammatory response
cell chemotaxis
phospholipase C-activating angiotensin-activated signaling pathway
positive regulation of cholesterol metabolic process
regulation of blood vessel diameter
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
positive regulation of reactive oxygen species metabolic process
blood vessel development
positive regulation of receptor recycling
regulation of systemic arterial blood pressure by circulatory renin-angiotensin
renin secretion into blood stream
regulation of renal output by angiotensin
brain renin-angiotensin system
regulation of pH
heart development
positive regulation of cell proliferation
positive regulation of cholesterol esterification
positive regulation of cellular protein metabolic process
positive regulation of phospholipase A2 activity
positive regulation of superoxide anion generation
regulation of smooth muscle cell apoptotic process
negative regulation of smooth muscle cell apoptotic process
vasoconstriction
dopamine biosynthetic process
drinking behavior
activation of Janus kinase activity
negative regulation of neuron apoptotic process
response to estrogen
positive regulation of blood pressure
positive regulation of cytokine secretion
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
cellular response to dexamethasone stimulus
positive regulation of branching involved in ureteric bud morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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