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Invitrogen
BACE1 VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA1336)
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Product Details
MA5-54393
Product Specifications
Species Reactivity
Human
Host/Isotype
Alpaca
/ VHH
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
SAA1336
Immunogen
Recombinant Human BACE1.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Metal-chelate chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
Product Specific Information
Compatible with Direct ELISA
Target Information
BACE1 (beta-secretase) is a key enzyme involved in the production of amyloid beta-peptides (Abeta) found in extracellular amyloid plaques of Alzheimer's disease (AD). In some cases early onset familial AD can be attributed to a "Swedish" mutation in the amyloid precursor protein (APP), which dramatically enhances the cleavage of this protein by BACE1. This and other genetic and pathological evidence has led to therapeutic approaches that have focused on the inhibition of BACE1 and other APP-cleaving enzymes, such as gamma-secretase stuff. APP is first cleaved by b-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for g-secretase to generate the 4 kDa amyloid-b peptide, which is deposited in the brains of all sufferers of Alzheimer's disease. The long-sought b-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). bACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: APP beta-secretase; asp 2; aspartyl protease 2; BACE; BACE 1; BACE-1B; BACE-1C; BACE-1D; BACE-I-432; BACEdelta7; Beta secretase; beta-site amyloid beta A4 precursor protein-cleaving enzyme; beta-site APP cleaving enzyme 1; beta-site APP processing enzyme; beta-site APP-cleaving enzyme; Memapsin; memapsin-2; Memapsin2; membrane type aspartyl protease; membrane-associated aspartic protease 2; transmembrane aspartic proteinase Asp2; unnamed protein product
Gene Aliases: ASP2; BACE; HSPC104
UniProt ID: (Human) P56817
Entrez Gene ID: (Human) 23621
proteolysis
membrane protein ectodomain proteolysis
response to lead ion
protein processing
beta-amyloid formation
swimming behavior
amyloid precursor protein catabolic process
regulation of neuron apoptotic process
positive regulation of neuron apoptotic process
beta-amyloid metabolic process
modulation of synaptic transmission
detection of mechanical stimulus involved in sensory perception of pain
prepulse inhibition
cellular response to copper ion
cellular response to manganese ion
presynaptic modulation of chemical synaptic transmission
signaling receptor ligand precursor processing
cellular response to beta-amyloid
amyloid fibril formation
response to insulin-like growth factor stimulus
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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