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Invitrogen
RhoB VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA1319)
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Product Details
MA5-54681
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Alpaca
/ VHH
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
SAA1319
Immunogen
Recombinant Human RHOB.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Metal-chelate chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
Target Information
Rho-related GTP-binding protein (RhoB) mediates apoptosis in neoplastically transformed cells after DNA damage. While not essential for development, it does affect cell adhesion and growth factor signaling in transformed cells. RhoB targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a tumor supressor - deletion of RhoB causes tumor formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Aplysia RAS-related homolog 6; ARHB; h6; oncogene RHO H6; ras homolog gene family, member B; Rho; rho cDNA clone 6; rho protein; rhoB; small GTP binding protein; unnamed protein product
Gene Aliases: ARH6; ARHB; MST081; MSTP081; RHOH6
UniProt ID: (Human) P62745
Entrez Gene ID: (Human) 388
mitotic cytokinesis
apoptotic process
actin filament organization
cell adhesion
signal transduction
small GTPase mediated signal transduction
Rho protein signal transduction
endosome to lysosome transport
positive regulation of endothelial cell migration
regulation of cell migration
positive regulation of cell migration
negative regulation of cell migration
positive regulation of apoptotic process
positive regulation of angiogenesis
negative regulation of cell cycle
endothelial tube morphogenesis
cellular response to hydrogen peroxide
cellular response to ionizing radiation
regulation of modification of postsynaptic structure
negative regulation of establishment of endothelial barrier
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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