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Invitrogen
Phospho-gamma-H2AX (Ser139) Recombinant Mouse Monoclonal Antibody (C6)
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Phospho-gamma-H2AX (Ser139) Antibody (MA5-54767) in SDS-PAGE
SDS-PAGE analysis of Phospho-gamma-H2AX (Ser139). Samples were run under reducing (R) and non-reducing (NR) conditions using Phospho-gamma-H2AX (Ser139) (Product # MA5-54767) monoclonal antibody. The purity of the protein is greater than 95%.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-54767
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, mFc VHH
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
C6
抗原
Recombinant Human Anti-Phospho-gamma-H2AX.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
3.69 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
靶标信息
H2AX is a variant of the H2A protein family and is a component of the histone octomer in nucleosomes. H2AX is phosphorylated by kinases such as ataxia telangiectasia mutated (ATM) and ATM-Rad3-related (ATR) in the PI3K pathway. Gamma-H2AX is the first step in recruiting and localizing DNA repair proteins. DSBs can be induced by mechanisms such as ionizing radiation or cytotoxic agents and subsequently, gamma-H2AX foci quickly form. These foci represent the DSBs in a 1:1 manner and can be used as a biomarker for damage. The visualization of gamma-H2AX by can allow the assessment of DNA damage, related DNA damage proteins and DNA repair. Gamma-H2AX has applications in the detection of genomic damage caused by cytotoxic chemical agents and environmental and physical damage.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: gamma H2A X; gamma H2A.X; gamma-H2A.X; gh2ax; H2a/x; Histone H2A.X; Histone H2AX
基因别名: H2AFX; H2AX
Entrez Gene ID: (Human) 3014
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