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Invitrogen
FGF2/VEGF (Eflimrufusp Alfa Biosimilar) Recombinant Human Monoclonal Antibody
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产品信息
MA5-54882
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1, kappa
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
抗原
Recombinant Human FGF2/bFGF and VEGFA.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
产品详细信息
Compatible with Direct ELISA
靶标信息
FGF2 (Fibroblast Growth Factor 2, basic FGF) is a member of the FGF family that regulates cell proliferation, differentiation, and angiogenesis through high-affinity cell surface FGF receptors. The human FGF2 gene is located on chromosome 4q. FGF2 is involved in limb and nervous system development, wound healing, and tumor growth. FGF2 exists as five isoforms generated by alternative translation from AUG and non-AUG (CUG) start codons. The 18 kDa isoform is mainly cytosolic and mediates paracrine and autocrine signaling through cell surface receptors. The higher molecular weight isoforms (22-34 kDa) localize to the nucleus and function through intracrine mechanisms independent of membrane receptors. Dysregulation of FGF2 has been associated with diseases such as Kaposi sarcoma and corneal neovascularization.
VEGF (Vascular Endothelial Growth Factor) is a 45 kDa homodimeric, disulfide-linked glycoprotein that is a central regulator of angiogenesis and tumor progression. It promotes endothelial cell survival, proliferation, migration, and vascular permeability. The VEGF family includes VEGF-A, -B, -C, -D, -E, and PlGF. VEGF signals primarily through the tyrosine kinase receptors VEGFR-1 (FLT1) and VEGFR-2 (KDR/FLK1), expressed mainly on endothelial cells. These pathways are essential for embryonic vascular development and tumor angiogenesis. Alternative splicing produces multiple VEGF isoforms with distinct properties. A soluble form of VEGFR-1 (sFLT1) can bind VEGF and inhibit angiogenesis. Elevated VEGF levels are associated with POEMS syndrome (Crow-Fukase syndrome).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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