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Invitrogen
Her-2/CD4 (Runimotamab Biosimilar) Recombinant Human Monoclonal Antibody
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产品信息
MA5-54985
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1, kappa
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
抗原
Recombinant Human CD340/ERBB2/HER2 and CD3E.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
产品详细信息
Compatible with Direct ELISA
靶标信息
HER2, also known as ErbB2, is a member of the epidermal growth factor receptor (EGFR/ErbB) family of receptor tyrosine kinases. Unlike other family members, HER2 has no known direct ligand and functions primarily through heterodimerization with other ErbB receptors, leading to activation of downstream signaling pathways such as PI3K/AKT and MAPK that regulate cell proliferation, survival, and differentiation. HER2 is overexpressed or amplified in several cancers, most notably breast and gastric cancers, where it is associated with aggressive disease and poor prognosis. Due to its role in tumor growth and its cell surface accessibility, HER2 is an important target for monoclonal antibodies, antibody-drug conjugates, and other targeted therapies.
The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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