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Invitrogen
FAP/IL2v (Simlukafusp alfa Biosimilar) Recombinant Human Monoclonal Antibody
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产品信息
MA5-54990
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1, kappa
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
抗原
Recombinant Human FAP/FAP alpha and IL2V.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
产品详细信息
Compatible with Direct ELISA
靶标信息
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.
IL2v is an engineered variant of interleukin-2 (IL-2) designed to selectively modulate immune activation. Unlike native IL-2, which binds both the high-affinity IL-2 receptor (CD25/CD122/CD132) and intermediate-affinity receptors, IL2v is modified to reduce or eliminate binding to the alpha chain (CD25). This selective receptor engagement preferentially stimulates effector T cells and natural killer (NK) cells while minimizing activation of regulatory T cells (Tregs), which can suppress anti-tumor immune responses. As a result, IL2v is being developed for cancer immunotherapy to enhance anti-tumor immunity with improved safety and reduced toxicity compared to traditional IL-2 therapy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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