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Invitrogen
CHD4 Recombinant Rabbit Monoclonal Antibody (0M3R5)
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FIGURE: 1 / 3
CHD4 Antibody (MA5-55408) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded Human spleen using CHD4 Recombinant Monoclonal Antibody (Product # MA5-55408) at a dilution of 1:200 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate Buffer (pH 6. 0) prior to IHC staining.
Product Details
MA5-55408
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
0M3R5
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1520-1700 of human CHD4.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.22 mg/mL
Amount
122 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
RRID
Product Specific Information
Immunogen Sequence: ELAEVEENKK MSQPGSPSPK TPTPSTPGDT QPNTPAPVPP AEDGIKIEEN SLKEEESIEG EKEVKSTAPE TAIECTQAPA PASEDEKVVV EPPEGEEKVE KAEVKERTEE PMETEPKGAA DVEKVEEKSA IDLTPIVVED KEEKKEEEEK KEVMLQNGET PKDLNDEKQK KNIKQRFMFN I
Target Information
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-dependent chromatin remodeler CHD4; ATP-dependent helicase CHD4; CHD-4; Chromo domain-containing protein 4; chromodomain-helicase-DNA-binding protein 4; Mi-2 autoantigen; Mi-2 autoantigen 218 kDa protein; Mi-2 beta; Mi2-beta; MI2B; unnamed protein product
Gene Aliases: 9530019N15Rik; AA617397; BC005710; CHD-4; CHD4; D6Ertd380e; Mi-2; Mi-2b; Mi-2beta; Mi2-BETA; mKIAA4075; SIHIWES
UniProt ID: (Human) Q14839, (Mouse) Q6PDQ2
Entrez Gene ID: (Human) 1108, (Mouse) 107932, (Rat) 117535
nucleotide binding
transcription cofactor binding
DNA binding
chromatin binding
transcription corepressor activity
protein binding
ATP binding
zinc ion binding
hydrolase activity
ATPase activity
nucleosomal DNA binding
histone binding
histone deacetylase binding
metal ion binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
DNA-binding transcription factor binding
ATP-dependent chromatin remodeler activity
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II repressing transcription factor binding
nucleic acid binding
helicase activity
microtubule binding
ATP-dependent helicase activity
transcription factor binding
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
molecular_function
negative regulation of transcription from RNA polymerase II promoter
double-strand break repair via homologous recombination
chromatin organization
chromatin remodeling
negative regulation of gene expression
oxygen transport
regulation of cell fate specification
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
regulation of synapse assembly
terminal button organization
regulation of stem cell differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
chromatin modification
ATP-dependent chromatin remodeling
spindle assembly
metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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