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Invitrogen
Aldolase A/B/C Recombinant Rabbit Monoclonal Antibody (PSH01-81)
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图: 1 / 13
Aldolase A/B/C Antibody (MA5-56379) in ICC/IF
Immunofluorescence analysis of Aldolase A/B/C using U-87 MG cells. The cells were fixed 4% paraformaldehyde for 20 minutes, permeabilized with 0.1% Triton™ X-100 in PBS for 5 minutes, and blocked with 1% BSA in 10% negative goat serum for 1 hour at room temperature. The cells were co-labeled with Aldolase A/B/C Recombinant Rabbit Monoclonal Antibody (PSH01-81) (Product # MA5-56379, green) and beta tublin (r... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-56379
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
PSH01-81
抗原
Synthetic peptide within human aldolase c aa 50-100.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
Positive Control: U-87 MG cell lysate, RAW264.7 cell lysate, C6 cell lysate, human brain tissue lysate, mouse brain tissue lysate, mouse pancreas tissue lysate, rat brain tissue lysate, rat pancreas tissue lysate, U-87 MG, mouse brain tissue, rat brain tissue.
Tissue Specificity: Group enriched (brain, retina).
Subcellular Location: cytoskeleton, cytosol, extracellular exosome, extracellular region.
Sequence Similarities: 100% Mouse/Rat.
Predicted band size: 110 kDa.
靶标信息
Aldolases are important glycolytic cytosolic enzymes which catalyse the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate. There are three aldolase isozymes coded by three distinct genes in mammals, namely aldolases A, B, and C. Aldolase A is heavily expressed in muscle enzyme and aldolase B is heavily expressed in liver and is regarded as a liver specific enzyme. In the adult, aldolase C is the brain-specific isozyme expressed in astrocytes and a few classes of neurons, notably Purkinje cells. Appropriate antibodies to aldolase C are therefore useful to identify astrocytes in cell culture and sectioned material, and the enzyme may be over expressed in some forms of cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ALDA; ALDB; ALDC; Aldolase 1; aldolase 1, A isoform; Aldolase 2; aldolase 2, B isoform; Aldolase 3; Aldolase B fructose-biphosphate; Aldolase B, fructose-biphosphate; aldolase C, fructose-biphosphate; Brain-type aldolase; Fructose-bisphosphate aldolase A; Fructose-bisphosphate aldolase B; Fructose-bisphosphate aldolase C; Liver-type aldolase; Lung cancer antigen NY-LU-1; Muscle-type aldolase; Scrapie-responsive protein 2; Zebrin II
基因别名: AI847350; ALDA; ALDB; ALDC; ALDCAA; Aldo-1; Aldo-2; Aldo1; Aldo2; Aldo3; ALDOA; ALDOB; ALDOC; AU040929; BC016435; F16dip7; LIV10; RATALDCAA; RNALDOG5; Scrg2
UniProt ID: (Mouse) P05064, (Rat) P05065, (Mouse) Q91Y97, (Mouse) P05063, (Rat) P09117
Entrez Gene ID: (Mouse) 11674, (Rat) 24189, (Mouse) 230163, (Rat) 24190, (Mouse) 11676, (Rat) 24191
fructose-bisphosphate aldolase activity
cytoskeletal protein binding
poly(A) RNA binding
fructose binding
protease binding
molecular_function
protein binding
catalytic activity
lyase activity
phosphatidylcholine binding
identical protein binding
ATPase binding
fructose-1-phosphate aldolase activity
aldolase
fructose metabolic process
glycolytic process
ATP biosynthetic process
striated muscle contraction
regulation of cell shape
fructose 1,6-bisphosphate metabolic process
muscle cell cellular homeostasis
response to hypoxia
response to heat
response to lipopolysaccharide
response to nicotine
response to estrogen
protein homotetramerization
NADH oxidation
response to zinc ion
positive regulation of ATPase activity
response to peptide hormone
vacuolar proton-transporting V-type ATPase complex assembly
liver development
response to carbohydrate
response to fructose
response to organic cyclic compound
cellular response to extracellular stimulus
cellular response to insulin stimulus
response to drug
response to starvation
response to amino acid
response to copper ion
response to glucocorticoid
response to cAMP
response to interleukin-6
apoptotic process
aging
response to organonitrogen compound
epithelial cell differentiation
organ regeneration
protein heterotetramerization
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