Phospho-SMAD2/SMAD3 (Ser465, Ser467, Ser423, Ser425) Recombinant Rabbit Monoclonal Antibody (ST0493)

RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding transforming growth factor beta receptor binding protein binding phosphatase binding ubiquitin protein ligase binding type I transforming growth factor beta receptor binding identical protein binding SMAD binding tau protein binding RNA polymerase II sequence-specific DNA binding transcription factor binding co-SMAD binding I-SMAD binding R-SMAD binding disordered domain specific binding DNA-binding transcription factor binding transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding transcription corepressor binding transcription coactivator binding collagen binding beta-catenin binding zinc ion binding ligand-dependent nuclear receptor binding DEAD/H-box RNA helicase binding enzyme binding protein kinase binding chromatin DNA binding mineralocorticoid receptor binding sterol response element binding glucocorticoid receptor binding protein homodimerization activity ubiquitin binding bHLH transcription factor binding sequence-specific DNA binding promoter-specific chromatin binding

negative regulation of transcription from RNA polymerase II promoter MAPK cascade skeletal system development osteoblast differentiation ureteric bud development response to hypoxia in utero embryonic development mesoderm formation somitogenesis release of cytochrome c from mitochondria liver development heart looping osteoblast development immune system development regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter apoptotic process immune response transforming growth factor beta receptor signaling pathway JNK cascade gastrulation endoderm development cell proliferation negative regulation of cell proliferation anatomical structure morphogenesis embryonic pattern specification response to gamma radiation gene expression positive regulation of gene expression negative regulation of gene expression positive regulation of alkaline phosphatase activity positive regulation of epithelial to mesenchymal transition regulation of striated muscle tissue development regulation of transforming growth factor beta receptor signaling pathway signal transduction involved in regulation of gene expression cell differentiation negative regulation of ossification negative regulation of cell growth adrenal gland development positive regulation of cell migration positive regulation of bone mineralization thyroid gland development positive regulation of chondrocyte differentiation positive regulation of interleukin-1 beta production regulation of transforming growth factor beta2 production positive regulation of transforming growth factor beta3 production activin receptor signaling pathway negative regulation of osteoblast proliferation cellular response to platelet-derived growth factor stimulus nodal signaling pathway T cell activation negative regulation of protein catabolic process response to cocaine negative regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process cell-cell junction organization positive regulation of nitric oxide biosynthetic process negative regulation of fat cell differentiation negative regulation of osteoblast differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter paraxial mesoderm morphogenesis developmental growth embryonic foregut morphogenesis embryonic cranial skeleton morphogenesis regulation of epithelial cell proliferation negative regulation of inflammatory response regulation of immune response protein stabilization positive regulation of positive chemotaxis negative regulation of cytosolic calcium ion concentration positive regulation of stress fiber assembly regulation of mitochondrial membrane potential positive regulation of focal adhesion assembly pericardium development transdifferentiation positive regulation of SMAD protein import into nucleus SMAD protein signal transduction regulation of dendritic spine morphogenesis negative regulation of wound healing trophoblast cell migration negative regulation of lung blood pressure lens fiber cell differentiation cellular response to glucose stimulus cellular response to growth factor stimulus response to transforming growth factor beta cellular response to transforming growth factor beta stimulus positive regulation of canonical Wnt signaling pathway apoptotic signaling pathway extrinsic apoptotic signaling pathway response to alcohol cellular response to virus transforming growth factor beta receptor superfamily signaling pathway positive regulation of extracellular matrix assembly negative regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of cardiac muscle hypertrophy in response to stress response to angiotensin regionalization determination of left/right asymmetry in lateral mesoderm aortic valve morphogenesis pulmonary valve morphogenesis endocardial cushion morphogenesis transcription, DNA-templated zygotic specification of dorsal/ventral axis mesoderm development anterior/posterior pattern specification positive regulation of BMP signaling pathway primary miRNA processing intracellular signal transduction cell fate commitment negative regulation of cell differentiation negative regulation of transcription, DNA-templated regulation of multicellular organismal process mesenchyme development secondary palate development response to cholesterol odontoblast differentiation endoderm formation protein phosphorylation pattern specification process heart development response to glucose post-embryonic development insulin secretion lung development pancreas development organ growth negative regulation of lipopolysaccharide-mediated signaling pathway developmental process wound healing positive regulation of protein import into nucleus negative regulation of transforming growth factor beta production regulation of miRNA transcription