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Invitrogen
CD85j (ILT2) Recombinant Rabbit Monoclonal Antibody (PSH04-59)
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CD85j (ILT2) Antibody (MA5-56429) in WB
Western blot analysis of CD85j (ILT2) in Lane 1: Raji cell lysate, Lane 2: Daudi cell lysate, Lane 3: THP-1 cell lysate, Lane 4: A431 cell lysate (negative), Lane 5: K-562 cell lysate (negative). (Lysates/Proteins at 20 µg/Lane). Samples were incubated with CD85j (ILT2) Recombinant Monoclonal Antibody (Product # MA5-56429) using a dilution of 1:1,000 Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST (1 hr, room temperature). Followed by using Goat Anti-Rabbit IgG-HRP Secondary Antibody at dilution 1:50,000 (1hr, ro... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-56429
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
PSH04-59
抗原
Recombinant protein within human LILRB1 aa 1-461/650.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
CD85j, also known as a member of the leukocyte immunoglobulin-like receptor (LIR) family, is a single transmembrane glycoprotein with a long cytoplasmic domain containing four immunoreceptor tyrosine-based inhibitory motifs (ITIMs). These motifs signal through interactions with SHP-1, transducing negative signals that inhibit immune response stimulation. CD85j is expressed on myeloid cells such as monocytes and dendritic cells, as well as on subsets of lymphoid cells including NK, T, and B cells. The expression of CD85j is correlated with leukemias such as acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL). On CD8+ cells, CD85j expression is associated with effector cell function and plays a significant role in viral infections, including HIV, Epstein-Barr virus, and cytomegalovirus (CMV). CD85j binds to MHC class I molecules, including HLA-G, A, F, B27, E, and F, on antigen-presenting cells. The receptor helps control inflammatory responses and cytotoxicity, focusing the immune response and limiting autoreactivity. CD85j belongs to the subfamily B class of LIR receptors, which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and multiple transcript variants encoding different isoforms have been identified for this gene. Its gene is located in a cluster at chromosomal region 19q13.4.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD85 antigen-like family member J; CD85j; ILT-2; Immunoglobulin-like transcript 2; Leukocyte immunoglobulin-like receptor subfamily B member 1; LIR-1; MIR-7; Monocyte/macrophage immunoglobulin-like receptor 7
基因别名: ILT2; LILRB1; LIR1; MIR7
Entrez Gene ID: (Human) 10859
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