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Invitrogen
Phospho-PAK4/6/7 (Ser474, Ser602, Ser560) Recombinant Rabbit Monoclonal Antibody (JE57-42)
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Phospho-PAK4/6/7 (Ser474, Ser602, Ser560) Antibody (MA5-56570) in WB
Western blot analysis of Phospho-PAK4/6/7 (Ser474, Ser602, Ser560) in Lane 1: A549 cell lysate (20 µg/Lane), Lane 2: HeLa cell lysate (20 µg/Lane), Lane 3: MCF7 cell lysate (20 µg/Lane), Lane 4: HUVEC cell lysate (10 µg/Lane), Lane 5: HUVEC treated with 50 ng/mL VEGF for 2 minutes cell lysate (30 µg/Lane). Samples were incubated with Phospho-PAK4/6/7 (Ser474, Ser602, Ser560) Recombinant Monoclonal Antibody ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-56570
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JE57-42
抗原
Synthetic phosphopeptide corresponding to residues surrounding Ser474 of human PAK4.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
TBS, pH 7.4, with 0.05% BSA, 40% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
PAK4 is highly expressed in prostate, testis and colon. PAK4 interacts tightly with GTP-bound but not GDP-bound CDC42 and weakly with RAC. PAK4 phosphorylates and autophosphorylates and also activates the JNK pathway. PAK5, a member of the PAK family of protein kinases contains a CDC42/Rac1 interactive binding (CRIB) motif at the N-terminus and a Ste20-like kinase domain at the C-terminus. PAK5 preferentially binds to CDC42 in the presence of GTP and the CRIB motif is essential for this interaction. PAK6 protein cotranslocates into the nucleus with androgen receptor, which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development, in response to androgen. PAK6 was initially identified as an androgen receptor in a yeast two hybrid screen and was found to be highly expressed in testis and prostate tissues. Later experiments have shown it to be activated by MAP kinase 6 and p38 MAP kinase, suggesting that PAK6 may play a role in the cellular response to stress-related signals.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: p21-activated kinase 4; p21-activated kinase 5; p21-activated kinase 6; p21-activated kinase 7; PAK 4/5/6; PAK 4/6/7; PAK-4; PAK-5; PAK-6; PAK-7; PAK4/5/6; Serine/threonine-protein kinase PAK 4; Serine/threonine-protein kinase PAK 5; Serine/threonine-protein kinase PAK 6
基因别名: KIAA1142; KIAA1264; PAK4; PAK5; PAK6; PAK7
Entrez Gene ID: (Human) 10298, (Human) 57144, (Human) 56924
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