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Invitrogen

PTP1B/PTPN2 Recombinant Rabbit Monoclonal Antibody (24GB1130)

View all (3) PTP1B/PTPN2 antibodies

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Product Details

MA5-56940

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:5,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-

Flow Cytometry (Flow)

1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293F

Class

Recombinant Monoclonal

Type

Antibody

Clone

24GB1130

Immunogen

A synthesized peptide derived from human PTP1B/PTPN2 (aa 11-66)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

50 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Dry ice (international)

RRID

AB_3679966

Target Information

PTP1B (Protein Tyrosine Phosphatase 1B), encoded by the PTPN1 gene located on chromosome 20q13.1, is a major regulator of several cellular signaling pathways, impacting diseases like diabetes, obesity, and various cancers. The protein structure includes multiple exons and functions as a non-transmembrane enzyme that negatively regulates signaling cascades, including insulin and leptin signaling, which are vital for metabolic homeostasis. PTPN2 (Protein Tyrosine Phosphatase Non-Receptor Type 2), located on chromosome 18p11.3-p11.2, also known as T-cell PTP, is similarly a non-transmembrane protein tyrosine phosphatase that modulates immune responses and cell growth. It has ten exons and produces two splice variants, impacting signaling pathways by regulating the phosphorylation state of key proteins. Both of these phosphatases are involved in the fine-tuning of signaling mechanisms that control cell growth, differentiation, and immune regulation, highlighting their importance in disease pathology and as potential therapeutic targets.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: MPTP; phosphotyrosyl-protein phosphatase (EC 3.1.3.48); protein tyrosine phosphatase 1B; protein tyrosine phosphatase, placental; protein-protein-tyrosine phosphatase HA2; Protein-tyrosine phosphatase 1B; Protein-tyrosine phosphatase HA2; Protein-tyrosine phosphatase PTP-2; Protein-tyrosine phosphatase PTP-S; PTP-1B; PTP-HA2; PTP1B; T cell protein-tyrosine phosphatase; T-cell protein tyrosine phosphatase; T-cell protein-tyrosine phosphatase; TCPTP; Tyrosine-protein phosphatase non-receptor type 1; Tyrosine-protein phosphatase non-receptor type 2; unnamed protein product

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Gene Aliases: AI325124; PTN2; Ptp; PTP-1B; PTP-HA2; PTP1B; PTPN1; PTPN2; PTPT; TC-PTP; TC45; TC48; TCELLPTP; TCPTP

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UniProt ID: (Human) P18031, (Human) P17706, (Rat) P20417, (Mouse) P35821, (Mouse) Q06180, (Rat) P35233

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Entrez Gene ID: (Human) 5770, (Human) 5771, (Rat) 24697, (Mouse) 19246, (Mouse) 19255, (Rat) 117063

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Function(s)
RNA binding phosphoprotein phosphatase activity protein tyrosine phosphatase activity non-membrane spanning protein tyrosine phosphatase activity insulin receptor binding protein binding zinc ion binding hydrolase activity phosphatase activity enzyme binding protein kinase binding receptor tyrosine kinase binding cadherin binding ephrin receptor binding protein phosphatase 2A binding integrin binding syntaxin binding STAT family protein binding poly(A) RNA binding DNA binding protein phosphatase
Process(es)
positive regulation of systemic arterial blood pressure protein dephosphorylation negative regulation of cell proliferation insulin receptor signaling pathway regulation of signal transduction negative regulation of signal transduction positive regulation of heart rate positive regulation of cardiac muscle cell apoptotic process negative regulation of cell-substrate adhesion negative regulation of neuron projection development actin cytoskeleton organization regulation of endocytosis regulation of proteolysis negative regulation of vascular endothelial growth factor receptor signaling pathway endoplasmic reticulum unfolded protein response response to nutrient levels cellular response to insulin stimulus regulation of intracellular protein transport cellular response to unfolded protein response to endoplasmic reticulum stress peptidyl-tyrosine dephosphorylation platelet-derived growth factor receptor-beta signaling pathway cellular response to platelet-derived growth factor stimulus IRE1-mediated unfolded protein response insulin receptor recycling negative regulation of MAP kinase activity cellular response to fibroblast growth factor stimulus positive regulation of JNK cascade regulation of insulin receptor signaling pathway negative regulation of insulin receptor signaling pathway negative regulation of protein kinase B signaling regulation of type I interferon-mediated signaling pathway JAK-STAT cascade involved in growth hormone signaling pathway negative regulation of ERK1 and ERK2 cascade cellular response to hypoxia cellular response to nitric oxide vascular endothelial cell response to oscillatory fluid shear stress regulation of postsynapse assembly regulation of hepatocyte growth factor receptor signaling pathway negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of IRE1-mediated unfolded protein response negative regulation of PERK-mediated unfolded protein response cellular response to angiotensin negative regulation of vascular associated smooth muscle cell migration cellular response to nerve growth factor stimulus response to angiotensin positive regulation of endothelial cell apoptotic process positive regulation of receptor catabolic process negative regulation of transcription from RNA polymerase II promoter negative regulation of tumor necrosis factor-mediated signaling pathway negative regulation of lipid storage B cell differentiation T cell differentiation erythrocyte differentiation negative regulation of epidermal growth factor receptor signaling pathway negative regulation of tyrosine phosphorylation of STAT protein glucose homeostasis negative regulation of macrophage differentiation positive regulation of gluconeogenesis negative regulation of JAK-STAT cascade negative regulation of inflammatory response negative regulation of T cell receptor signaling pathway negative regulation of chemotaxis regulation of interferon-gamma-mediated signaling pathway negative regulation of interferon-gamma-mediated signaling pathway negative regulation of type I interferon-mediated signaling pathway negative regulation of interleukin-6-mediated signaling pathway negative regulation of interleukin-2-mediated signaling pathway negative regulation of interleukin-4-mediated signaling pathway negative regulation of macrophage colony-stimulating factor signaling pathway negative regulation of positive thymic T cell selection positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of PERK-mediated unfolded protein response negative regulation of platelet-derived growth factor receptor-beta signaling pathway actin cytoskeleton reorganization peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity activation of JUN kinase activity dephosphorylation positive regulation of protein tyrosine kinase activity negative regulation of tyrosine phosphorylation of Stat3 protein negative regulation of tyrosine phosphorylation of Stat5 protein negative regulation of tyrosine phosphorylation of Stat6 protein negative regulation of protein tyrosine kinase activity negative regulation of prolactin signaling pathway negative regulation of tyrosine phosphorylation of Stat1 protein
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